Antigrippin effervescent tablets for children, # 30

The tablets are round, flat, with a beveled edge and a dividing line on one side, pink in color with lighter and darker blotches, randomly located, with a fruity odor.

PHARMACOTHERAPEUTIC GROUP:

A remedy for eliminating the symptoms of acute respiratory infections and colds" (analgesic non-narcotic drug + vitamin + H1-histamine receptor blocker).

ATX code [N02BE51]

PHARMACOLOGICAL PROPERTIES:

Combined drug.

Paracetamol has analgesic and antipyretic effects

eliminates headaches and other types of pain, reduces fever.

Ascorbic acid (vitamin C) is involved in the regulation of redox processes, carbohydrate metabolism, increases the body's resistance.

Chlorphenamine - a blocker of H1-histamine receptors, has an anti-allergic effect, facilitates breathing through the nose, reduces nasal congestion, sneezing, watery eyes, itching and redness of the eyes.

INDICATIONS FOR USE:

Infectious and inflammatory diseases (ARVI, influenza), accompanied by fever, chills, headache, pain in the joints and muscles, nasal congestion and pain in the throat and sinuses.

CONTRAINDICATIONS:

Hypersensitivity to paracetamol, ascorbic acid, chlorphenamine or any other component of the drug.

Erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase).

Severe renal and / or hepatic impairment.

Angle-closure glaucoma.

Children's age (up to 3 years old).

With caution - renal and / or hepatic failure, deficiency of glucose-6-phosphate dehydrogenase, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), viral hepatitis.

DOSAGE AND METHOD OF APPLICATION:

Inside.

Children from 3 to 5 years old 1/2 tablet 2 times a day

children from 5 to 10 years old, 1 tablet 2 times a day

children from 10 to 15 years old, 1 tablet 2-3 times a day.

The tablet should be completely dissolved in a glass (200 ml) of warm water (50-60? C) and the resulting solution should be drunk immediately.

Better to take the drug between meals.

The interval between doses of the drug should be at least 4 hours.

In patients with impaired liver or kidney function, the interval between doses of the drug should be at least 8 hours.

Duration of admission without consulting a doctor is not more than 5 days when prescribed as an anesthetic and 3 days as an antipyretic agent.

SIDE EFFECTS:

The drug is well tolerated in the recommended doses.

In isolated cases, there are:

from the side of the central nervous system: headache, feeling of fatigue

from the gastrointestinal tract: nausea, pain in the epigastric region

from the endocrine system: hypoglycemia (up to the development of coma)

on the part of the hematopoietic organs: anemia, hemolytic anemia (especially for patients with glucose-6-phosphate dehydrogenase deficiency)

extremely rare - thrombocytopenia

allergic reactions: skin rash, itching, urticaria, Quincke's edema

others: hypervitaminosis, metabolic disorders, feeling of heat, dry mouth, accommodation paresis, urinary retention, drowsiness.

All side effects of the drug should be reported to your doctor.

OVERDOSE:

Symptoms of an overdose of the drug are due to its constituent substances.

The clinical picture of an acute paracetamol overdose develops within 6-14 hours after taking it.

Symptoms of chronic overdose appear 2-4 days after increasing the dose of the drug.

Symptoms of an acute paracetamol overdose: diarrhea, decreased appetite, nausea and vomiting, abdominal discomfort and / or abdominal pain, increased sweating.

Chlorphenamine overdose symptoms: dizziness, agitation, sleep disturbances, depression, convulsions.

Treatment: symptomatic.

INTERACTION WITH OTHER MEDICINAL PRODUCTS:

Ethanol enhances the sedative effect of antihistamines.

Antidepressants, antiparkinsonian drugs, antipsychotics (phenothiazine derivatives) - increase the risk of side effects (urinary retention, dry mouth, constipation).

Glucocorticosteroids - increase the risk of developing glaucoma.

With simultaneous use, it reduces the chronotropic effect of isoprenaline.

Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxications with small overdoses.

Ethanol contributes to the development of acute pancreatitis.

Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic effects.

Simultaneous administration of the drug and diflunisal increases the concentration of paracetamol in the blood plasma by 50%, increasing hepatotoxicity.

Simultaneous reception of barbiturates reduces the effectiveness of paracetamol, increases the excretion of ascorbic acid in the urine.

Paracetamol reduces the effectiveness of uricosuric drugs.

SPECIAL INSTRUCTIONS:

If you are taking metoclopramide, domperidone, or cholestyramine, you should also consult your doctor.

With prolonged use in doses significantly higher than recommended, the likelihood of impaired liver and kidney function increases, monitoring of the peripheral blood picture is necessary.

Paracetamol and ascorbic acid can distort laboratory tests (quantitative determination of glucose and uric acid in blood plasma, bilirubin, activity of "hepatic" transaminases, LDH).

The administration of ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors can aggravate the process.

In patients with an increased iron content in the body, ascorbic acid should be used in minimal doses.

RELEASE FORM:

Effervescent tablets for children.

10 tablets in a plastic case

1, 2, 4 or 6 tablets in a strip of Al / Al.

1, 3, 5, 6, 10, 15, 20 strips in a cardboard box together with instructions for use.

1 pencil case in a cardboard box or an envelope box with a hanging device along with instructions for use.

STORAGE CONDITIONS:

At a temperature of 10-30 ° C.

Keep out of the reach of children!

SHELF LIFE:

3 years.

Do not use after the expiration date.

TERMS OF RELEASE FROM PHARMACIES: without prescription.

Dosage

paracetamol …………………………………………………………………………. 250.00 mg

ascorbic acid …………………………………………………………………… 50.00 mg

chlorphenamine maleate …………………………………………………………………. 3.00 mg

Structure

COMPOSITION PER ONE TABLET:

Active substances:

paracetamol …………………………………………………………………………. 250.00 mg

ascorbic acid …………………………………………………………………… 50.00 mg

chlorphenamine maleate …………………………………………………………………. 3.00 mg

Excipients: sodium bicarbonate 740.00 mg

citric acid 830.00 mg

sorbitol 745.50 mg

povidone 12.50 mg

sodium saccharinate 30.00 mg

sodium carbonate 100.00 mg

macrogol 90.00 mg

silicon dioxide 9.00 mg

fruit flavoring (aromatic fruit additive "Red fruits") 140.00 mg.

INN / Active ingredient

Paracetamol + Chlorphenamine + Ascorbic acid

Storage conditions and periods

Store at a temperature not exceeding 10C-30C

Specifications

Category

Pain and fever

Scope of the medicinal product

General

Release form

Tablet

Manufacturer country

Poland

Package quantity, pcs

thirty

Minimum age from

3 years old

Way of introduction

Through the mouth

Vacation conditions

Without recipe

Brand name

Natur Produkt

The amount of the dosage form in the primary package

6 pcs.

Primary packaging type

Cell-free contoured packaging (strip)

Type of consumer packaging

Pack of cardboard

Dosage form

Pills

A type

Medicine

The target audience

Children

Package weight, g

135

Mode of application

:

Inside.

Children from 3 to 5 years old 1/2 tablet 2 times a day

children from 5 to 10 years old, 1 tablet 2 times a day

children from 10 to 15 years old, 1 tablet 2-3 times a day.

The tablet should be completely dissolved in a glass (200 ml) of warm water (50-60C) and the resulting solution should be drunk immediately.

Better to take the drug between meals.

The interval between doses of the drug should be at least 4 hours.

In patients with impaired liver or kidney function, the interval between doses of the drug should be at least 8 hours.

Duration of admission without consulting a doctor is not more than 5 days when prescribed as an anesthetic and 3 days as an antipyretic agent.

Pharmaco-therapeutic group

:

ARI and "cold" symptoms remedy (analgesic non-narcotic drug + H1-histamine receptor blocker + vitamin)

Anatomical and therapeutic characteristics

:

N02BE51 Paracetamol, in combination with other drugs (excluding psychotropic drugs)

Information on technical characteristics, delivery set, country of manufacture "