Antigrippin effervescent raspberry tablets, No. 10

Infectious and inflammatory diseases (ARVI flu) accompanied by fever, chills, headache, pain in the joints and muscles, nasal congestion and pain in the throat and sinuses.

Inside. Adults and children over 15 years old take 1 tablet 2-3 times a day. The tablet should be completely dissolved in a glass (200 ml) of warm water (50-60 ? C) and the resulting solution should be drunk immediately. Better to take the drug between meals. The maximum daily dose is 3 tablets. The interval between doses of the drug should be at least 4 hours.

In patients with impaired liver or kidney function and in elderly patients, the interval between doses of the drug should be at least 8 hours.

Duration of admission without consulting a doctor is not more than 5 days when prescribed as an anesthetic and 3 days as an antipyretic agent.

Active substances:

paracetamol - 500.00 mg

chlorphenamine maleate - 10.00 mg

ascorbic acid - 200.00 mg

Excipients: sodium bicarbonate 826.40 mg, citric acid 950.40 mg, sorbitol 700.00 mg, povidone 25.00 mg, sodium saccharinate 30.00 mg, sodium carbonate 93.00 mg, macrogol 70.00 mg, sodium lauryl sulfate 0.20 mg, lime flavor (aromatic fruit additive 'Lime') 95.00 mg.

- Hypersensitivity to paracetamol, ascorbic acid, chlorphenamine or any other component of the drug;

- Erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase);

- Severe renal and / or hepatic impairment;

- Alcoholism;

- Angle-closure glaucoma;

- Phenylketonuria;

- Hyperplasia of the prostate;

- Children's age (up to 15 years old);

- Pregnancy and lactation.

Carefully:

Renal and / or hepatic failure deficiency of glucose-6-phosphate dehydrogenase congenital hyperbilirubinemia (Gilbert Dubin-Johnson and Rotor syndromes) viral hepatitis alcoholic hepatitis elderly age.

Pharmacodynamics:

Combined drug.

Paracetamol has analgesic and antipyretic effects; eliminates headaches and other types of pain and reduces fever.

Ascorbic acid (vitamin C) is involved in the regulation of the redox processes of carbohydrate metabolism and increases the body's resistance.

Chlorphenamine - a blocker of H1-histamine receptors has an anti-allergic effect; facilitates breathing through the nose; reduces the feeling of nasal congestion; sneezing; lacrimation; itching and redness of the eyes.

Side effects:

The drug is well tolerated in the recommended doses.

In isolated cases, there are:

from the side of the central nervous system: headache feeling of fatigue;

from the gastrointestinal tract: nausea; pain in the epigastric region;

from the endocrine system: hypoglycemia (up to the development of coma);

on the part of the hematopoietic organs: hemolytic anemia anemia (especially for patients with glucose-6-phosphate dehydrogenase deficiency); extremely rare - thrombocytopenia;

allergic reactions: skin rash itching urticaria angioedema;

others: hypervitaminosis metabolic disorder feeling of heat dry mouth paresis of accommodation urinary retention drowsiness.

All side effects of the drug should be reported to your doctor.

Overdose:

Symptoms of an overdose of the drug are due to its constituent substances. The clinical picture of an acute overdose of paracetamol develops within 6-14 hours after taking it. Symptoms of chronic overdose appear 2-4 days after the overdose.

Symptoms of acute paracetamol intoxication: diarrhea, decreased appetite, nausea and vomiting, abdominal discomfort and / or abdominal pain, increased sweating.

Symptoms of chlorphenamine intoxication: dizziness, agitation of sleep disturbances, depression, convulsions.

Treatment: symptomatic.

Interaction:

Ethanol enhances the sedative effect of antihistamines.

Antidepressants antiparkinsonian drugs antipsychotics (phenothiazine derivatives) - increase the risk of side effects (urinary retention, dry mouth, constipation). Glucocorticosteroids - increase the risk of developing glaucoma.

With simultaneous use, it reduces the chronotropic effect of isoprenaline.

Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives tubular reabsorption of amphetamine and tricyclic antidepressants.

Inducers of microsomal oxidation in the liver (phenytoin ethanol barbiturates rifampicin phenylbutazone tricyclic antidepressants) increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxication with small overdoses. Ethanol contributes to the development of acute pancreatitis.

Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic effects. Simultaneous administration of the drug and diflunisal increases the concentration of paracetamol in the blood plasma by 50%, hepatotoxicity increases. Simultaneous reception of barbiturates reduces the effectiveness of paracetamol increases the excretion of ascorbic acid in the urine.

Paracetamol reduces the effectiveness of uricosuric drugs.

Special instructions:

If you are taking metoclopramide domperidone or cholestyramine, you should also consult your doctor.

With prolonged use in doses significantly exceeding the recommended, the likelihood of impaired liver and kidney function increases, it is necessary to control the peripheral blood picture.

Paracetamol and ascorbic acid can distort laboratory tests (quantitative determination of glucose and uric acid in the blood plasma bilirubin activity of 'hepatic' LDH transaminases).

In order to avoid toxic damage to the liver, paracetamol should not be combined with the intake of alcoholic beverages and should also be taken by persons prone to chronic alcohol consumption. The risk of developing liver damage increases in patients with alcoholic hepatosis. The administration of ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors can aggravate the course of the process. In patients with an increased iron content in the body, ascorbic acid should be used in minimal doses.