Analgin tab. 500 mg # 20 Renewal

Special Price $5.82 Regular Price $14.00
In stock
SKU
OTC102038285
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Category

Pain relievers

,

Migraine

,

Pain and fever

Scope of the drug

General

Release form

Tablet

Manufacturer country

Russia

Package quantity, pcs

twenty

Description

Release form, composition and packaging

Pills

1 tab.

metamizole sodium

500 mg

10 pieces.

- non-cell contoured packaging (1) - cardboard packs.

10 pieces.

- contour cell packaging (1) - cardboard packs.

20 pcs.

- cans (1) - packs of cardboard.

30 pcs.

- cans (1) - packs of cardboard.

pharmachologic effect

Analgesic antipyretic.

Derived from pyrazolone.

It has analgesic, antipyretic and anti-inflammatory effects, the mechanism of which is associated with inhibition of prostaglandin synthesis.

Pharmacokinetics

After oral administration, metamizole sodium is rapidly hydrolyzed in gastric juice with the formation of an active metabolite of 4-methyl-amino-antipyrine, which, after absorption, is metabolized into 4-formyl-amino-antipyrine and other metabolites.

After intravenous administration, metamizole sodium quickly becomes unavailable for determination.

Metamizole sodium metabolites do not bind to plasma proteins.

Most of the dose is excreted in the urine in the form of metabolites.

Metabolites are excreted in breast milk.

Indications for use

Pain syndrome of various origins (renal and biliary colic, neuralgia, myalgia with injuries, burns, after operations headache, toothache, menalgia).

Fever in infectious and inflammatory diseases.

Contraindications for use

Severe renal and / or liver dysfunction, deficiency of glucose-6-phosphate dehydrogenase, blood diseases, hypersensitivity to pyrazolone derivatives.

Dosage regimen

Inside or rectally, adults are prescribed 250-500 mg 2-3 times / day.

The maximum single dose is 1 g, the daily dose is 3 g. Single doses for children aged 2-3 years are 50-100 mg

4-5 years old - 100-200 mg

6-7 years old - 200 mg

8-14 years old - 250-300 mg

frequency of admission - 2-3 times / day.

In / m or / in slowly for adults - 250-500 mg 2-3 times / day.

The maximum single dose is 1 g, the daily dose is 2 g. In children, it is used parenterally at a dose of 50-100 mg per 10 kg of body weight.

Side effect

Allergic reactions: skin rash, Quincke's edema

rarely - anaphylactic shock.

From the hematopoietic system: rarely, with prolonged use - leukopenia, agranulocytosis.

Local reactions: with intramuscular injection - infiltrates at the injection site.

Drug interactions

With simultaneous use with analgesics-antipyretics, with NSAIDs, mutual intensification of toxic effects is possible.

With simultaneous use with inducers of microsomal liver enzymes, it is possible to reduce the effectiveness of metamizole sodium.

With simultaneous use, the activity of indirect anticoagulants, oral hypoglycemic drugs, GCS, indomethacin increases due to their displacement from the connection with blood proteins under the influence of sodium metamizole.

With simultaneous use with phenothiazine derivatives, severe hyperthermia is possible

with sedatives, anxiolytics - the analgesic effect of metamizole sodium is enhanced

with tricyclic antidepressants, oral contraceptives, allopurinol - the metabolism of metamizole sodium is disrupted and its toxicity increases

with caffeine - the effect of sodium metamizole is enhanced

with cyclosporine - the concentration of cyclosporine in the blood plasma decreases.

When metamizole sodium is used in combination with pitofenone hydrochloride (it has a direct myotropic effect on the smooth muscles of internal organs and causes its relaxation) and with fenpiverinium bromide (m-anticholinergic blocker), their pharmacological action is mutually reinforced, which is accompanied by a decrease in pain, relaxation of smooth muscles and a decrease in elevated body temperature.

Application during pregnancy and lactation

Use with caution during pregnancy, especially in the first trimester and in the last 6 weeks.

special instructions

With prolonged use, it is necessary to control the peripheral blood picture.

Metamizole sodium is used in combination with pitofenone and fenpiverinium bromide as an analgesic with an antispasmodic effect.

Use with caution in children in the first 3 months of life.

Name ENG

ANALGIN

Clinical and pharmacological group

Analgesic antipyretic

ATX code

Metamizole sodium

Dosage

500mg

Structure

The active ingredient is metamizole sodium - 500 mg excipients: potato starch, talc, sodium lauryl sulfate, calcium stearate.

Indications

Weak or moderate pain syndrome (headache, migraine, toothache, neuralgia, myalgia dysmenorrhea postoperative pain in combination with antispasmodics for renal and biliary colic)

febrile conditions in infectious and inflammatory diseases

use as an antipyretic agent is advisable after the diagnosis of the disease.

Contraindications

Hypersensitivity to pyrazolone derivatives (butadione, tribuzone), a tendency to bronchospasm.

Severe liver or kidney dysfunction, deficiency of glucose-6-phosphate dehydrogenase, blood diseases.

Storage conditions and periods

In a dark place at a temperature not exceeding 25 degrees.

Expiration date: 5 years

INN / Active ingredient

Metamizole sodium

Specifications

Category

Pain relievers

,

Migraine

,

Pain and fever

Scope of the drug

General

Release form

Tablet

Manufacturer country

Russia

Package quantity, pcs

twenty

Way of introduction

Through the mouth

Vacation conditions

Without recipe

Brand name

Renewal

The amount of the dosage form in the primary package

10 pieces.

Primary packaging type

Blister

Type of consumer packaging

Pack of cardboard

Pharmaco-therapeutic group

Analgesic non-narcotic drug

Anatomical and therapeutic characteristics

N02BB02 Metamizole sodium

Dosage form

Pills

Dosage (volume) of the substance in the preparation

500 mg

Expiration date in days

1825

The target audience

Children

Package weight, g

ten

Mode of application

:

For adults and adolescents over 15 years old is 500 mg. < br> The maximum dose can reach 1000 mg up to 2-3 times a day. < br> The maximum daily dose is 3000 mg. < br> Duration of admission is no more than 5 days when prescribed as an anesthetic funds and no more than 3 days as an antipyretic agent.

< br> The tablets should be taken with a sufficient amount of water.

< br> For children aged 2-3 years 50-100 mg

4-5 years old - 100-200 mg

6-7 years old - 200 mg < br> 8-14 years old - 250-300 mg 2-3 times a day. < br> Children from 2 to 5 years old (weighing from 15 to 20 kg) - 1 supp ...

(200 mg) 1-4 times a day with an interval of 6 to 8 hours.

Information on technical characteristics, delivery set, country of manufacture

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