Analgin tab. 500 mg # 20 Renewal
Category
Pain relievers
,
Migraine
,
Pain and fever
Scope of the drug
General
Release form
Tablet
Manufacturer country
Russia
Package quantity, pcs
twenty
Release form, composition and packaging
Pills
1 tab.
metamizole sodium
500 mg
10 pieces.
- non-cell contoured packaging (1) - cardboard packs.
10 pieces.
- contour cell packaging (1) - cardboard packs.
20 pcs.
- cans (1) - packs of cardboard.
30 pcs.
- cans (1) - packs of cardboard.
pharmachologic effect
Analgesic antipyretic.
Derived from pyrazolone.
It has analgesic, antipyretic and anti-inflammatory effects, the mechanism of which is associated with inhibition of prostaglandin synthesis.
Pharmacokinetics
After oral administration, metamizole sodium is rapidly hydrolyzed in gastric juice with the formation of an active metabolite of 4-methyl-amino-antipyrine, which, after absorption, is metabolized into 4-formyl-amino-antipyrine and other metabolites.
After intravenous administration, metamizole sodium quickly becomes unavailable for determination.
Metamizole sodium metabolites do not bind to plasma proteins.
Most of the dose is excreted in the urine in the form of metabolites.
Metabolites are excreted in breast milk.
Indications for use
Pain syndrome of various origins (renal and biliary colic, neuralgia, myalgia with injuries, burns, after operations headache, toothache, menalgia).
Fever in infectious and inflammatory diseases.
Contraindications for use
Severe renal and / or liver dysfunction, deficiency of glucose-6-phosphate dehydrogenase, blood diseases, hypersensitivity to pyrazolone derivatives.
Dosage regimen
Inside or rectally, adults are prescribed 250-500 mg 2-3 times / day.
The maximum single dose is 1 g, the daily dose is 3 g. Single doses for children aged 2-3 years are 50-100 mg
4-5 years old - 100-200 mg
6-7 years old - 200 mg
8-14 years old - 250-300 mg
frequency of admission - 2-3 times / day.
In / m or / in slowly for adults - 250-500 mg 2-3 times / day.
The maximum single dose is 1 g, the daily dose is 2 g. In children, it is used parenterally at a dose of 50-100 mg per 10 kg of body weight.
Side effect
Allergic reactions: skin rash, Quincke's edema
rarely - anaphylactic shock.
From the hematopoietic system: rarely, with prolonged use - leukopenia, agranulocytosis.
Local reactions: with intramuscular injection - infiltrates at the injection site.
Drug interactions
With simultaneous use with analgesics-antipyretics, with NSAIDs, mutual intensification of toxic effects is possible.
With simultaneous use with inducers of microsomal liver enzymes, it is possible to reduce the effectiveness of metamizole sodium.
With simultaneous use, the activity of indirect anticoagulants, oral hypoglycemic drugs, GCS, indomethacin increases due to their displacement from the connection with blood proteins under the influence of sodium metamizole.
With simultaneous use with phenothiazine derivatives, severe hyperthermia is possible
with sedatives, anxiolytics - the analgesic effect of metamizole sodium is enhanced
with tricyclic antidepressants, oral contraceptives, allopurinol - the metabolism of metamizole sodium is disrupted and its toxicity increases
with caffeine - the effect of sodium metamizole is enhanced
with cyclosporine - the concentration of cyclosporine in the blood plasma decreases.
When metamizole sodium is used in combination with pitofenone hydrochloride (it has a direct myotropic effect on the smooth muscles of internal organs and causes its relaxation) and with fenpiverinium bromide (m-anticholinergic blocker), their pharmacological action is mutually reinforced, which is accompanied by a decrease in pain, relaxation of smooth muscles and a decrease in elevated body temperature.
Application during pregnancy and lactation
Use with caution during pregnancy, especially in the first trimester and in the last 6 weeks.
special instructions
With prolonged use, it is necessary to control the peripheral blood picture.
Metamizole sodium is used in combination with pitofenone and fenpiverinium bromide as an analgesic with an antispasmodic effect.
Use with caution in children in the first 3 months of life.
Name ENG
ANALGIN
Clinical and pharmacological group
Analgesic antipyretic
ATX code
Metamizole sodium
Dosage
500mg
Structure
The active ingredient is metamizole sodium - 500 mg excipients: potato starch, talc, sodium lauryl sulfate, calcium stearate.
Indications
Weak or moderate pain syndrome (headache, migraine, toothache, neuralgia, myalgia dysmenorrhea postoperative pain in combination with antispasmodics for renal and biliary colic)
febrile conditions in infectious and inflammatory diseases
use as an antipyretic agent is advisable after the diagnosis of the disease.
Contraindications
Hypersensitivity to pyrazolone derivatives (butadione, tribuzone), a tendency to bronchospasm.
Severe liver or kidney dysfunction, deficiency of glucose-6-phosphate dehydrogenase, blood diseases.
Storage conditions and periods
In a dark place at a temperature not exceeding 25 degrees.
Expiration date: 5 years
INN / Active ingredient
Metamizole sodium
Specifications
Category
Pain relievers
,
Migraine
,
Pain and fever
Scope of the drug
General
Release form
Tablet
Manufacturer country
Russia
Package quantity, pcs
twenty
Way of introduction
Through the mouth
Vacation conditions
Without recipe
Brand name
Renewal
The amount of the dosage form in the primary package
10 pieces.
Primary packaging type
Blister
Type of consumer packaging
Pack of cardboard
Pharmaco-therapeutic group
Analgesic non-narcotic drug
Anatomical and therapeutic characteristics
N02BB02 Metamizole sodium
Dosage form
Pills
Dosage (volume) of the substance in the preparation
500 mg
Expiration date in days
1825
The target audience
Children
Package weight, g
ten
Mode of application
:
For adults and adolescents over 15 years old is 500 mg. < br> The maximum dose can reach 1000 mg up to 2-3 times a day. < br> The maximum daily dose is 3000 mg. < br> Duration of admission is no more than 5 days when prescribed as an anesthetic funds and no more than 3 days as an antipyretic agent.
< br> The tablets should be taken with a sufficient amount of water.
< br> For children aged 2-3 years 50-100 mg
4-5 years old - 100-200 mg
6-7 years old - 200 mg < br> 8-14 years old - 250-300 mg 2-3 times a day. < br> Children from 2 to 5 years old (weighing from 15 to 20 kg) - 1 supp ...
(200 mg) 1-4 times a day with an interval of 6 to 8 hours.
Information on technical characteristics, delivery set, country of manufacture