Amoxiclav Kviktab dispersible tablets 500 + 125mg, No. 14

Infections caused by susceptible strains of microorganisms:

• infections of the upper respiratory tract and ENT organs (acute and chronic sinusitis, acute and chronic otitis media, retropharyngeal abscess, tonsillitis, pharyngitis);

• lower respiratory tract infections (acute bronchitis with bacterial superinfection, chronic bronchitis, pneumonia);

• urinary tract infections;

• infections in gynecology;

• infections of the skin and soft tissues, including human and animal bites;

• bone and connective tissue infections;

• biliary tract infections (cholecystitis, cholangitis);

• odontogenic infections.

Amoxiclav Kviktab tablets are taken orally, after dissolving in half a glass of water (at least 30 ml) and mixing thoroughly. It is possible to hold the tablets in the mouth until they are completely dissolved, and then swallow.

In order to reduce the risk of side effects from the gastrointestinal tract, the drug should be taken at the beginning of a meal.

Adults and children over 12 years of age (weighing> 40 kg) with mild to moderate infection are prescribed 1 tablet (625 mg) every 12 hours, in case of severe infection and respiratory tract infections - 1 tablet (625 mg) every 8 hours or 1 tablet (1000 mg) every 12 hours.

The duration of treatment is up to 14 days.

In the case of starting treatment with parenteral administration of the drug, it is possible to continue therapy with oral administration of Amoxiclav Kviktab tablets.

In accordance with the severity of the functional impairment of the kidneys, the dose of the drug should be reduced and / or the interval of use should be increased. With renal failure of moderate severity (CC 10-30 ml / min), 1 tablet (625 mg) is prescribed every 12 hours.

Dispersible tablets of light yellow color with brown blotches, oblong, octagonal, with a fruity odor.

1 tab.

amoxicillin trihydrate 574 mg,?

which corresponds to the content of amoxicillin 500 mg

potassium clavulanate 148.87 mg,?

which corresponds to the content of clavulanic acid 125 mg

Excipients: tropical mixture flavor, sweet orange flavor, aspartame, colloidal anhydrous silicon dioxide, iron (III) oxide yellow (E172), talc, hydrogenated castor oil, microcrystalline silicon-containing cellulose.

• Hypersensitivity to any component of the drug;

• a history of hypersensitivity to any antibiotic from the group of penicillins, cephalosporins, and other beta-lactam antibiotics;

• a history of indications of cholestatic jaundice and / or other liver dysfunction caused by taking amoxicillin / clavulanic acid;

With care: a history of pseudomembranous colitis, liver failure, severe renal dysfunction, lactation.

Due to the fact that in a large number of patients with infectious mononucleosis and lymphocytic leukemia, who received ampicillin, the appearance of an erythematous rash was observed, the use of antibiotics of the ampicillin group in such patients is not recommended.

pharmachologic effect

Combined preparation of amoxicillin and clavulanic acid - a beta-lactamase inhibitor. Acts bactericidal, inhibits the synthesis of the bacterial wall.

Active against aerobic gram-positive bacteria (including strains producing beta-lactamase): Staphylococcus aureus; aerobic gram-negative bacteria: Enterobacter spp., Escherichia coli, Haemophilus influenzae, Klebsiella spp., Moraxella catarrhalis. The following pathogens are sensitive only in vitro: Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus anthracis, Streptococcus pneumoniae, Streptococcus viridans, Enterococcus faecalis, Corynebacterium spp., Listeria monocytogenes; anaerobic Clostridium spp., Peptococcus spp., Peptostreptococcus spp .; as well as aerobic gram-negative bacteria (including strains producing beta-lactamases): Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp., Bordetella pertussis, Yersinia enterocolitica, Gardnerella vaginalis, Neisseria meningitidis,Neisseria gonorrhoeae, Haemophilus ducreyi, Yersinia multocida (formerly Pasteurella), Campylobacter jejuni; anaerobic gram-negative bacteria (including strains producing beta-lactamases): Bacteroides spp., including Bacteroides fragilis.

Clavulanic acid inhibits types II, III, IV and V beta-lactamases, is inactive against type I beta-lactamases produced by Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp. Clavulanic acid has a high tropism for penicillinases, due to which it forms a stable complex with the enzyme, which prevents the enzymatic degradation of amoxicillin under the influence of beta-lactamases.

Pharmacokinetics

After oral administration, both components are rapidly absorbed in the gastrointestinal tract. Concomitant food intake does not affect absorption. TCmax - 45 min. After oral administration at a dose of 250/125 mg every 8 hours Cmax of amoxicillin - 2.18-4.5 ?g / ml, clavulanic acid - 0.8-2.2 ?g / ml, at a dose of 500/125 mg every 12 hours Cmax of amoxicillin - 5.09-7.91 ?g / ml , clavulanic acid - 1.19-2.41 ?g / ml, at a dose of 500/125 mg every 8 hours Cmax of amoxicillin - 4.94-9.46 ?g / ml, clavulanic acid - 1.57-3.23 ?g / ml, at a dose of 875/125 mg Cmax of amoxicillin - 8.82 -14.38 ?g / ml, clavulanic acid - 1.21-3.19 ?g / ml.

Side effect

From the digestive system: nausea, vomiting, diarrhea, gastritis, stomatitis, glossitis, increased activity of hepatic transaminases, in isolated cases - cholestatic jaundice, hepatitis, liver failure (more often in the elderly, men, with prolonged therapy), pseudomembranous and hemorrhagic colitis ( can also develop after therapy), enterocolitis, black 'hairy' tongue, darkening of tooth enamel.

From the side of hematopoietic organs: a reversible increase in prothrombin time and bleeding time, thrombocytopenia, thrombocytosis, eosinophilia, leukopenia, agranulocytosis, hemolytic anemia.

From the nervous system: dizziness, headache, hyperactivity, anxiety, change in behavior, seizures.

Local reactions: in some cases - phlebitis at the intravenous injection site.

Allergic reactions: urticaria, erythematous rash, rarely - exudative erythema multiforme, anaphylactic shock, angioedema, extremely rarely - exfoliative dermatitis, malignant exudative erythema (Stevens-Johnson syndrome), serous allergic vasculitis, pustular syndrome, similar to acute ...

Others: candidiasis, development of superinfection, interstitial nephritis, crystalluria, hematuria.

Application during pregnancy and lactation

Use with caution during pregnancy and lactation (breastfeeding).

special instructions

During the course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.

In order to reduce the risk of side effects from the gastrointestinal tract, the drug should be taken with meals.

The development of superinfection is possible due to the growth of microflora insensitive to it, which requires a corresponding change in antibiotic therapy.

May give false positive results for glucose in urine. In this case, it is recommended to use the glucose-oxidative method for determining the concentration of glucose in the urine.

In patients with hypersensitivity to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.

Drug interactions

Antacids, glucosamine, laxatives, aminoglycosides slow down and reduce absorption; ascorbic acid enhances absorption.

Bacteriostatic antibiotics (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) have an antagonistic effect.

Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index). With the simultaneous administration of anticoagulants, it is necessary to monitor the indicators of blood clotting.

Reduces the effectiveness of oral contraceptives, drugs, in the process of metabolism of which PABA is formed, ethinyl estradiol - the risk of bleeding 'breakthrough'.

Diuretics, allopurinol, phenylbutazone, NSAIDs and other drugs that block tubular secretion increase the concentration of amoxicillin (clavulanic acid is excreted mainly by glomerular filtration).

Allopurinol increases the risk of skin rashes.