Ambroxol tablets 30mg, No. 20

Respiratory tract diseases with the formation of viscous sputum:

acute and chronic bronchitis,

pneumonia,

chronic obstructive pulmonary disease (COPD),

bronchial asthma with difficulty in sputum discharge,

bronchiectasis,

cystic fibrosis.

Inside, during meals, with a small amount of liquid.

Adults and children over 12 years of age are prescribed - 30 mg 3 times a day. in the first 2-3 days, then 30 mg 2 times a day. or 15 mg (half a tablet) 3 times a day.

Children 6-12 years old - 15 mg (half a tablet) 2-3 times a day. It is not recommended to use without medical prescription for more than 4-5 days.

ambroxol hydrochloride

Hypersensitivity, children under 6 years of age, pregnancy (I trimester).

With caution: The drug should be used with caution in patients with gastric ulcer and duodenal ulcer, as well as in patients with renal and hepatic insufficiency.

pharmachologic effect

Mucolytic agent, stimulates prenatal lung development (increases synthesis, secretion of surfactant and blocks its breakdown). It has a secretomotor, secretolytic and expectorant effect; stimulates serous cells of the glands of the bronchial mucosa, increases the content of mucous secretions and the release of a surfactant (surfactant) in the alveoli and bronchi; normalizes the disturbed ratio of serous and mucous components of sputum. By activating hydrolyzing enzymes and increasing the release of lysosomes from Clarke cells, it reduces the viscosity of sputum. Increases the motor activity of the ciliated epithelium, increases mucociliary transport. After oral administration, the effect occurs after 30 minutes and lasts for 6-12 hours. Pharmacokinetics

Absorption is high, the time to reach Cmax is 2 hours, the connection with plasma proteins is 80%. Penetrates the blood-brain barrier, placental barrier, excreted in breast milk. Metabolism - in the liver, forms dibromantranilic acid and glucuronic conjugates. T1 / 2 - 7-12 hours. Excreted by the kidneys: 90% in the form of water-soluble metabolites, unchanged - 5%. T1 / 2 increases with severe chronic renal failure, does not change with impaired liver function.

Side effect

Allergic reactions: skin rash, urticaria, angioedema, in some cases - allergic contact dermatitis, anaphylactic shock. Rarely - weakness, headache, diarrhea, dry mouth and respiratory tract, exanthema, rhinorrhea, constipation, dysuria. With prolonged use in high doses - gastralgia, nausea, vomiting.

Application during pregnancy and lactation

The drug is not recommended for use during the first trimester of pregnancy. If it is necessary to use Ambroxol in the II-III trimesters of pregnancy and during breastfeeding, the potential benefit to the mother with a possible risk to the fetus / child should be assessed.

Application for violations of liver function

The drug should be used with caution in patients with hepatic impairment.

Application for impaired renal function

The drug should be used with caution in patients with renal impairment.

Application in children

Contraindicated in children under 6 years of age.

special instructions

Should not be combined with antitussive drugs that impede the excretion of sputum.

Overdose

Symptoms: nausea, vomiting, diarrhea. Treatment: artificial vomiting, gastric lavage in the first 1-2 hours after taking the drug; taking fat-containing foods.

Drug interactions

Combined use with antitussive drugs leads to difficulty in sputum discharge against the background of a decrease in cough. Increases penetration into the bronchial secretions of amoxicillin, cefuroxime, erythromycin and doxycycline.