Ambrohexal tablets 30mg, No. 20

Acute and chronic diseases of the respiratory tract with the production of viscous sputum:

- acute and chronic bronchitis;

-chronic obstructive pulmonary disease (solution, tablets);

-pneumonia;

- bronchial asthma with difficulty in sputum discharge;

- bronchiectasis;

-treatment and prevention of respiratory distress syndrome (solution).

Inside, after meals with a sufficient amount of liquid.

Pills

Adults and children over 12 years old: 1 tab. (30 mg ambroxol) 3 times a day for the first 2-3 days, then the dose of the drug must be reduced to 1 table. 2 times a day.

Children aged 6 to 12 years: 1/2 table. (15 mg ambroxol) 2-3 times a day. It is not recommended to use it without a doctor's prescription for more than 4Ц5 days.

During treatment, it is necessary to consume a lot of fluids (juices, tea, water), because it enhances the mucolytic effect of the drug.

Sustained-release capsules

Adults and children over the age of 12: 1 caps. (75 mg ambroxol) daily in the morning or evening after meals, without chewing and drinking plenty of fluids (water, tea or juice).

It is not recommended to use without medical prescription for more than 4-5 days. During treatment, it is necessary to consume a lot of fluids (juices, tea, water), because it enhances the mucolytic effect of the drug.

Solution for oral administration and inhalation

Adults and children over the age of 12 years: the first 2-3 days - 3 times 4 ml (30 mg Ambroxol) per day, then 2 times 4 ml.

Children aged 5-12 years: 2-3 times a day, 2 ml (15 mg of ambroxol).

Children aged 2 to 5 years: 3 times a day, 1 ml (7.5 mg of ambroxol).

Children under 2 years of age: 2 times a day, 1 ml (7.5 mg of ambroxol).

For children under 2 years of age, AmbroGEXALЃ is prescribed only under the supervision of a physician.

AmbroGEXALЃ should be taken after meals in diluted form with tea, fruit juices, milk or water.

During treatment, it is necessary to consume a lot of fluids (juices, tea, water) to enhance the mucolytic effect of the drug.

Application for inhalation

Adults and children over 5 years of age: it is recommended to inhale 1-2 times a day, 2-3 ml (40-60 drops, which corresponds to 15-22.5 mg of ambroxol).

Children under 5 years of age: it is recommended to inhale 1Ц2 times a day, 2 ml (40 drops, which corresponds to 15 mg of ambroxol).

For inhalation, it is necessary to use a suitable device in accordance with the rules of use.

The duration of therapy depends on the severity of the disease and is determined by the attending physician. AmbroGEXALЃ should not be taken for more than 4-5 days without a doctor's recommendation.

The tablets are white, round, flat, with beveled edges, with a notch on one side.

1 tab. ambroxol hydrochloride 30 mg

Excipients: lactose monohydrate - 102 mg, calcium hydrogen phosphate dihydrate - 50 mg, corn starch - 10 mg, carboxymethy

• Hypersensitivity to the components of the drug;

• pregnancy (I trimester).

• peptic ulcer of the stomach and duodenum

  With caution: patients with renal and hepatic impairment.

pharmachologic effect

Ambrohexal is a drug with mucolytic, secretolytic and expectorant effects, and the active ingredient of the drug is ambroxol.

The mechanism of action of this drug is associated with a decrease in the viscosity of sputum as a result of depolymerization of mucopolysaccharides in sputum, which consists in breaking disulfide bonds in molecules, enhancing the release of active hydrolyzing enzymes from Clark cells.

Also, Ambrohexal increases the activity of the cilia of the bronchial epithelium, and normalizes the ratio of all components of sputum and, therefore, stimulates its mucociliary transport. This makes it easier to cough up phlegm from the respiratory tract, and also stimulates the secretion and blockage of the breakdown of the surfactant.

Ambrohexal is rapidly absorbed from the gastrointestinal tract, having a high absorption capacity, and its optimal concentration in plasma is achieved within two hours after taking the drug: tablets, syrup, capsules with prolonged action and a solution for inhalation.

The effect of the drug occurs when taken in the form of a syrup or tablets - after 30 minutes and depends on the rate of absorption of the drug in the stomach and intestines. This drug is metabolized in the liver, where it is converted to dobramantranilic acid and glucuronic conjugates, and excreted by the kidneys.

Application during pregnancy and lactation

The drug is contraindicated for use during the first trimester of pregnancy.

The use of AmbrohexalЃ during pregnancy (II-III trimester) is possible only if the intended benefit to the mother outweighs the potential risk to the fetus or baby.

Ambroxol crosses the placental barrier. Animal studies have shown that the drug has no effect on embryofetal development, childbirth and postnatal development.

Ambroxol is excreted in breast milk in small amounts, therefore, when taking AmbrohexalЃ, it is necessary to resolve the issue of stopping breastfeeding.

Side effects

From the digestive system: nausea, vomiting, gastralgia, diarrhea, constipation, dry mouth.

Allergic reactions: skin rash, urticaria, angioedema, bronchospasm attack, fever with chills; anaphylactic shock; weakness, headache, rhinorrhea, increased salivation, dryness in the airways, impaired urination (dysuria).

Interaction

Combined use with antitussive drugs leads to difficulty in sputum discharge against the background of suppression of the cough reflex. Increases penetration into the bronchial secretions of amoxicillin, cefuroxime, erythromycin and doxycycline.

Overdose

Symptoms: nausea, vomiting, gastralgia. There are reports of short-term anxiety and diarrhea. With a pronounced overdose, a drop in blood pressure is possible.

Treatment: induction of vomiting, gastric lavage in the first 1-2 hours after taking the drug, prescribing fat-containing products.

Special instructions

Ambroxol should be used with caution in patients with a weakened cough reflex or impaired mucociliary transport due to the possibility of sputum accumulation.

Patients taking ambroxol should not be advised to perform breathing exercises; in critically ill patients, aspiration of liquefied sputum should be performed.

In patients with bronchial asthma, ambroxol may aggravate the cough.

You should not take Ambroxol just before bed.

Ambroxol should not be taken concurrently with antitussive drugs that can inhibit the cough reflex, such as codeine. this can make it difficult to remove liquefied sputum from the bronchial tree.

Indication for patients with diabetes mellitus: 1 tablet contains less than 0.01 XE.