Almagel A oral suspension 10ml, No. 10 sachet

• peptic ulcer of the stomach and duodenum in the acute phase;

• acute gastritis and chronic gastritis with increased and normal secretory function in the acute phase;

• duodenitis;

• enteritis;

• hernia of the esophageal opening of the diaphragm;

• reflux esophagitis;

• functional bowel disorders, colitis;

• discomfort and pain in the epigastrium with errors in the diet, after drinking coffee, nicotine, alcohol;

• prophylactically in the treatment of corticosteroids and NSAIDs.

• In the complex of therapeutic measures, Almagel A is prescribed for patients with diabetes.

Inside. As prescribed by the doctor, 1-3 dosage (teaspoons) spoons, depending on the severity of the case, 3-4 times / day half an hour before meals and in the evening before bedtime.

In children, the drug is used strictly according to the doctor's prescription: children under 10 years old are prescribed 1/3 of the dose for adults, and children from 10 to 15 years old - 1/2 dose for adults.

For diseases accompanied by nausea, vomiting and abdominal pain, treatment begins with Almagel A, and after the disappearance of the listed symptoms, they switch to Almagel. Shake the bottle before taking.

10 ml (1 sachet) suspension contains:

Active ingredients:

Aluminum hydroxide gel - 4.36 g

in terms of Al2O3 - 436 mg

Magnesium hydroxide paste - 700 mg

in terms of MgO - 150 mg

Benzocaine -218 mg

Excipients:

Hydrogen peroxide solution 30% - 0.82 mg, sorbitol - 1602.30 mg, hyetellose - 30.52 mg, methyl parahydroxybenzoate - 21.80 mg, propyl parahydroxybenzoate - 2.726 mg, butyl parahydroxybenzoate - 2.726 mg, sodium saccharinate dihydrate - 1.636 mg, propylene glycol - 654.00 mg, macrogol 4000 - 436.00 mg, lemon oil - 3.27 mg, ethanol 96% - 196.20 mg, purified water up to 10 ml.

• hypersensitivity to drug components;

• severe renal dysfunction;

• Alzheimer's disease;

• early childhood (up to 1 month).

• Do not prescribe simultaneously with sulfonamides due to the presence of benzocaine in the drug.

pharmachologic effect

Almagel A neutralizes free hydrochloric acid in the stomach, which leads to a decrease in the digestive activity of gastric juice. Does not cause secondary hypersecretion of gastric juice. It has a local anesthetic, adsorbing and enveloping effect, reduces the effect of damaging factors on the mucous membrane. The therapeutic effect after taking the drug occurs in 3-5 minutes and lasts an average of 70 minutes. Almagel A provides long-term local neutralization of continuously secreting gastric juice and reduces the content of hydrochloric acid in it to the optimal limits for treatment. Aluminum hydroxide inhibits the secretion of pepsin, neutralizes hydrochloric acid, forming aluminum chloride, which is converted into alkaline aluminum salts in the alkaline medium of the intestine. Magnesium hydroxide also neutralizes hydrochloric acid,turning into magnesium chloride. In this way, the constipation-causing effect of aluminum hydroxide is counteracted. Magnesium hydroxide and magnesium chloride are resorbed to an insignificant extent and practically do not affect the concentration of magnesium ions in the blood. Benzocaine has an effective and long-lasting local analgesic effect in severe pain. Sorbitol, which is part of the drug, promotes increased bile secretion and exhibits a mild laxative effect, complementing the effect of magnesium hydroxide. Almagel A does not sharply increase the pH of the stomach contents, buffers its value from 4.0-4.5 to 3.5-3.8 (physiological value) between doses. The drug forms a protective layer,ensuring a uniform distribution of active substances on the gastric mucosa and has a long-term local effect without the subsequent formation of carbon dioxide in the stomach, which, in turn, causes flatulence, a feeling of heaviness in the epigastric region and a secondary increase in the secretion of hydrochloric acid. According to the classification of Hodge and Sterner, the drug, when administered orally, is classified as a weakly toxic agent and does not have embryotoxic, teratogenic and mutagenic effects. In some cases, increased tendon reflexes were noted in newborns whose mothers had been taking the drug for a long time. In addition, in newborns there is a risk of developing hypermagnesemia, especially in a state of dehydration, therefore, prolonged use of the drug for pregnant women and newborns is not recommended.

Pharmacokinetics

Almagel A is a non-absorbable drug. If the correct dosage regimen and the duration of treatment are observed, it is practically not resorbed in the gastrointestinal tract and has a long-term uniform effect without disturbing the electrolyte balance and without creating a risk of alkalosis or other metabolic disorders. It does not irritate the urinary system and, with prolonged use, does not cause alkalosis and the formation of calculi in the urinary tract.

Side effect

In some cases, when taking the drug, there may be a change in taste, nausea, vomiting, stomach cramps, pain in the epigastric region and constipation, which disappear after reducing the dose. May cause drowsiness at high doses. Long-term treatment with high doses of the drug and food poor in phosphorus can lead in predisposed patients to the development of phosphorus deficiency in the body, increased resorption and excretion of calcium in the urine and the occurrence of osteomalacia. Therefore, with prolonged use of the drug, an adequate intake of phosphorus with food should be ensured. In patients with chronic renal failure, in addition to osteomalacia, edema of the extremities, dementia and hypermagnesemia may be observed.

Application during pregnancy and lactation

It is not recommended to prescribe Almagel A for more than 3 days during pregnancy. Avoid prescribing to nursing mothers.

Application for impaired renal function

Contraindicated: severe renal dysfunction.

Application in children

Contraindicated: early childhood (up to 1 month). In children, the drug is used strictly according to the doctor's prescription: children under 10 years old are prescribed 1/3 of the dose for adults, and children from 10 to 15 years old - 1/2 dose for adults.

special instructions

The interval between taking Almagel A and other medicines should be 1-2 hours. It is not recommended to take the drug in doses exceeding 16 spoons per day, or, if such a dose is used, the duration of the course of treatment should be no more than 2 weeks. With prolonged use of the drug, an adequate intake of phosphorus with food should be ensured.

Drug interactions

With the simultaneous use of Almagel A, it can reduce the therapeutic effect of tetracycline antibiotics, histamine H2 receptor blockers, digitalis glycosides, iron salts, ciprofloxacin, phenothiazines, isoniazid, beta-blockers, indomethacin and ketokenozole, etc.