Allapinin tablets 25mg, No. 30

• Supraventricular and ventricular premature beats

• Paroxysms of atrial fibrillation and atrial flutter

• Paroxysmal supraventricular tachycardia, including with Wolff-Parkinson-White syndrome (WPW, paroxysmal ventricular tachycardia (in the absence of organic lesions of the heart).

Inside, after a meal, with a small amount of water at room temperature; do not grind.

1 table. (25 mg) every 8 hours, in the absence of a therapeutic effect - every 6 hours.

An increase in a single dose to 2 tablets is possible. (50 mg) every 6-8 hours.

The maximum daily dose is 300 mg (12 tablets).

The duration of treatment and correction of the dosage regimen (dose increase) is determined by the doctor.

Active ingredient:
Allapinin - 25 mg
Excipients: sucrose (sugar), potato starch, calcium stearate (calcium stearic acid).

• Hypersensitivity to the drug,

• sinoatrial blockade,

• atrioventricular block II and III degree (without a pacemaker),

• cardiogenic shock,

• blockade of the right branch of the bundle of His, combined with a blockade of one of the branches of the left leg,

• blockade of intraventricular conduction,

• severe arterial hypotension,

• chronic heart failure

• severe hypertrophy of the left ventricular myocardium (? 1.4 cm),

• the presence of postinfarction cardiosclerosis,

• severe liver and / or kidney dysfunction,

• pregnancy,

• lactation period,

• age up to 18 years (efficacy and safety have not been established).

Use with caution in case of atrioventricular blockade of 1 degree, violation of intraventricular conduction, sick sinus syndrome, bradycardia, severe circulatory disorders, angle-closure glaucoma, prostatic hypertrophy, impaired conduction along the Purkinje fibers, blockade of one of the legs of the bundle of His, impaired electrolyte metabolism ( hyperkalemia, hypomagnesemia).

Trade name: AllapininЃ

Chemical Name: hydrobromic salt of lappaconitine alkaloid / (1a, 14a, 16?) - 1,14,16-Trimethoxy-N-ethylaconitane-4, 8, 9-triol 4- [2- (acetylamino) benzoate] with accompanying alkaloids

Dosage form:

pills

Composition
Active ingredient:
Allapinin - 25 mg
Excipients: sucrose (sugar), potato starch, calcium stearate (calcium stearic acid).

Description
Tablets are round, biconvex, white.

Pharmacotherapeutic group:

antiarrhythmic agent

ATX code: C01BG

Pharmacological properties
AllapininЃ is a hydrobromic salt of the alkaloid lappaconitine with accompanying alkaloids, obtained from the herb of the white-mouth wrestler - Aconitum leucostomum Worosch. and rhizomes with roots of the northern fighter (high fighter) - Aconitum septentrionale Koelle (A. excelsum Reichenb.), fam. Buttercup - Ranunculaceae.

Pharmacodynamics
Class 1 antiarrhythmic drug, white-mouth aconite alkaloid. Blocks 'fast' sodium channels of cardiomyocyte membranes. It slows down atrioventricular and intraventricular conduction, shortens the effective and functional refractory periods of the atria, AV node, His bundle and Purkinje fibers, does not affect the duration of the QT interval, conduction along the AV node in the anterograde direction, heart rate and blood pressure, myocardial contractility (with the initial absence of symptoms of heart failure). Does not inhibit automatism (sinus node. It does not have negative inotropic and hypotensive effects. It has a moderate antispasmodic, coronary dilating, anticholinergic, local anesthetic and sedative effect.When taken orally, the effect develops after 40-60 minutes, reaches a maximum after 4-5 hours and lasts 8 hours or more.

Pharmacokinetics
Bioavailability is 40%, has the effect of 'first pass' through the liver. Penetrates the blood-brain barrier. The half-life is 1-1.2 hours. It is excreted by the kidneys. With prolonged use, it is possible to lengthen the half-life, with chronic renal failure by 2-3 times, cirrhosis of the liver - by 3-10 times. The volume of distribution for oral administration is 690 liters.

Indications for use

• Supraventricular and ventricular premature beats

• Paroxysms of atrial fibrillation and atrial flutter

• Paroxysmal supraventricular tachycardia, including with Wolff-Parkinson-White syndrome (WPW, paroxysmal ventricular tachycardia (in the absence of organic lesions of the heart).

Contraindications

• Hypersensitivity to the drug,

• sinoatrial blockade,

• atrioventricular block II and III degree (without a pacemaker),

• cardiogenic shock,

• blockade of the right branch of the bundle of His, combined with a blockade of one of the branches of the left leg,

• blockade of intraventricular conduction,

• severe arterial hypotension,

• chronic heart failure

• severe hypertrophy of the left ventricular myocardium (? 1.4 cm),

• the presence of postinfarction cardiosclerosis,

• severe liver and / or kidney dysfunction,

• pregnancy,

• lactation period,

• age up to 18 years (efficacy and safety have not been established).

Use with caution in case of atrioventricular blockade of 1 degree, violation of intraventricular conduction, sick sinus syndrome, bradycardia, severe circulatory disorders, angle-closure glaucoma, prostatic hypertrophy, impaired conduction along the Purkinje fibers, blockade of one of the legs of the bundle of His, impaired electrolyte metabolism ( hyperkalemia, hypomagnesemia).

Dosing and Administration
Inside. It is advisable to grind it before taking the pill. The drug is taken 30 minutes before meals, washed down with warm water, 1 tablet 3 times a day, in the absence of a therapeutic effect - 2 tablets 3-4 times a day. The highest single dose is 0.15 g, the daily dose is 0.3 g. The onset of action after a single dose is 40-60 minutes, the total duration of action is over 8 hours. In severe chronic renal failure, a dose reduction is required. The duration of treatment is determined by the doctor.

Side effect
When taking AllapininЃ, dizziness, headache, a feeling of heaviness in the head, skin hyperemia, ataxia, diplopia, allergic reactions are possible, intraventricular and atrioventricular conduction disturbances are possible, the appearance of sinus tachycardia (with prolonged use), arrhythmogenic effect, changes : lengthening of the PQ interval, expansion of the QRS complex.

Overdose
No information.

Interaction with other drugs
Inducers of liver microsomal enzymes reduce the effectiveness, increase the risk of toxic effects. Antiarrhythmics of other classes increase the risk of arrhythmogenic effects. Enhances the effect of non-depolarizing muscle relaxants.

Special instructions
In case of headache, dizziness, diplopia, the dose of the drug should be reduced. With the appearance of sinus tachycardia against the background of prolonged use of the drug, beta-blockers (small doses) are indicated.

Release form
Tablets of 25 mg.
10 or 30 tablets in blisters. 3 contour packaging No. 10 or 1 contour packaging No. 30 together with instructions for use are placed in a cardboard box for consumer packaging.

Storage conditions
List B. In the dark place, at a temperature not exceeding 25 ? C. Keep out of the reach of children.

Shelf life is
3 years. Do not use the drug after the expiration date.

Terms of dispensing from pharmacies
Prescription.

Manufacturer / Consumer claims should be sent to the address:
ZAO Pharmcenter VILAR
117216, Moscow, st. Green, 7