Alkoklin Glutargin powder for solution for oral administration, No. 10 Limion

Prevention of alcohol intoxication and hepatotoxic effects. Treatment of acute alcoholic intoxication of mild and moderate severity, as well as in the complex therapy of post-intoxication disorders after acute alcoholic poisoning of severe degree.

The drug is prescribed for adults inside, regardless of food intake, after dissolving the package in 1 / 4-1 / 2 glass of water.

For the prevention of intoxication and hepatotoxic effects of alcohol, 2 packets (2 g of arginine glutamate) are prescribed 1-2 hours before alcohol intake or 1 packet (1 g of arginine glutamate) 1 hour before alcohol intake and 1 packet (1 g of arginine glutamate) for 0.5 hours after drinking alcohol.

For the treatment of acute alcohol intoxication of mild and moderate severity, 1 sachet (1 g of arginine glutamate) is prescribed 4 times a day at intervals of 1Ц2.5 h, in the next 2-3 days - 1 sachet (1 g of arginine glutamate) 2 times per day. In case of severe alcohol poisoning, after a course of intravenous administration of the drug Glutargin, 1 packet (1 g of arginine glutamate) Glutargin alkocline is prescribed 2 times a day for 20 days as part of complex therapy.

active ingredient: arginine glutamate (in terms of 100% substance) 1.0 g.

excipients: glycine, mannitol (E 421), citric acid (anhydrous), aspartame (E 951), lemon flavor.

- hypersensitivity to drug components

- children under 18 years old

- During pregnancy and breastfeeding

- phenylketonuria since the drug contains aspartame

Carefully:

- febrile condition

- increased excitability

- severe violations of the filtration (nitrogen-releasing) renal function (creatinine clearance less than 30 ml / min)

Dosage form

powder for oral solution

Composition

In 1 package:

active ingredient: arginine glutamate (in terms of 100% substance) 1.0 g.

excipients: glycine 0.50 g, mannitol (E 421) 0.79 g, citric acid (anhydrous) 0.60 g, aspartame (E 951) 0.06 g, lemon flavor 0.05 g.

Description

Powder from white to white with a yellowish sheen, with a fruity odor.

Pharmacotherapeutic group

Hepatoprotective agent

ATX code

A05BA

Pharmacodynamics:

Glutargin alkocline is a compound of arginine and glutamic acid, which play an important role in providing biochemical processes of neutralization and excretion of a highly toxic metabolite of nitrogenous substances - ammonia from the body. It has a hepatoprotective effect, possessing antioxidant antitoxic and membrane-stabilizing activity, and has a positive effect on the processes of energy supply in hepatocytes.

In case of alcohol intoxication, Glutargin alkocline stimulates the utilization of alcohol in the monooxygenase system of the liver and prevents the inhibition of the key enzyme of ethanol utilization - alcohol dehydrogenase; accelerates the inactivation and elimination of toxic products of ethanol metabolism as a result of an increase in the formation and oxidation of succinic acid; reduces the depressing effect of alcohol on the central nervous system due to the neurotransmitter properties of excitatory glutamic acid.

Glutargin alkocline does not have embryotoxic gonadotoxic and mutagenic effects, does not cause allergic and immunotoxic reactions.

Pharmacokinetics:

Has not been studied.

Indications:

Prevention of alcohol intoxication and hepatotoxic effects. Treatment of acute alcoholic intoxication of mild and moderate severity, as well as in the complex therapy of post-intoxication disorders after acute alcoholic poisoning of severe degree.

Contraindications:

- hypersensitivity to drug components

- children under 18 years old

- During pregnancy and breastfeeding

- phenylketonuria since the drug contains aspartame

Carefully:

- febrile condition

- increased excitability

- severe violations of the filtration (nitrogen-releasing) renal function (creatinine clearance less than 30 ml / min)

Method of administration and dosage:

The drug is prescribed for adults inside, regardless of food intake, after dissolving the package in 1 / 4-1 / 2 glass of water.

For the prevention of intoxication and the hepatotoxic effect of alcohol, 2 packages (2 g of arginine glutamate) are prescribed 1-2 hours before drinking alcohol or 1 package (1 g of arginine glutamate) 1 hour before alcohol intake and 1 package (1 g of arginine glutamate) for 05 hours after drinking alcohol.

For the treatment of acute alcoholic intoxication of mild and moderate severity, 1 sachet (1 g of arginine glutamate) is prescribed 4 times a day at intervals of 1-25 hours in the next 2-3 days - 1 sachet (1 g of arginine glutamate) 2 times a day. In case of severe alcohol poisoning, after a course of intravenous use of the drug Glutargin, 1 packet (1 g of arginine glutamate) Glutargin alkocline is prescribed 2 times a day for 20 days as part of complex therapy.

Side effects:

Rarely, there may be a feeling of slight discomfort in the epigastric region and nausea immediately after using the drug, which pass on their own.

Overdose:

Symptoms: nausea vomiting pain in the chest area feeling of discomfort in the epigastric region insomnia transient short-term lowering of blood pressure atrioventricular block allergic reactions.

Treatment : symptomatic, if necessary, taking antihistamines in severe cases - intravenous glucocorticosteroids.

Interaction:

Care should be taken when combining Glutargin with the following drugs:

aminophylline increases the concentration of endogenous insulin in the blood under the influence of Glutargin alkocline. Glutargin alkocline can enhance the effect of antiplatelet agents (dipyridamole, etc.) prevents and weakens neurotoxic phenomena that may occur during isoniazid therapy and weakens the effect of vinblastine.

Special instructions:

When prescribing to patients with dysfunction of the endocrine glands, it should be borne in mind that the drug may slightly increase the secretion of insulin and growth hormone, which does not require correction of drug therapy in patients with diabetes mellitus and / or acromegaly.

Impact on the ability to drive vehicles. Wed and fur .:

The drug does not affect the ability to drive vehicles.

Release form / dosage:

Powder for preparation of oral solution 10 g.

Packaging:

3 g of powder (1 g of arginine glutamate) in a bag (No. 1) or in twin bags (No. 2); two, five or ten bags (No. 1) or five paired bags (No. 2) in a cardboard box.

Storage conditions:

Store in its original packaging at a temperature not exceeding 25 ? C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the expiration date indicated on the package.

Vacation conditions

Without recipe

Manufacturer

LLC 'Pharmaceutical company' Health ', 61013, Ukraine, Kharkov, st. Shevchenko, 22, Ukraine