Alflutop solution for injection 2ml, No. 10

Alflutop is used in adults with primary and secondary osteoarthritis of various localization (coxarthrosis, gonarthrosis, arthrosis of small joints), osteochondrosis and spondylosis.

In case of polyosteoarthritis and osteochondrosis, the drug is administered deeply intramuscularly, 1 ml per day. The course of treatment is 20 injections (1 injection per day for 20 days).
With a predominant lesion of large joints, the drug is administered intra-articularly by 1-2 ml into each joint with an interval of 3-4 days. A total of 5-6 injections in each joint for a course.
A combination of intra-articular and intramuscular methods of administration is possible. It is advisable to repeat the course of treatment 6 months after consulting a doctor.

1 ampoule with a capacity of 1 ml contains:
Active substance: bioactive concentrate 0.1 ml
Excipients: phenol (max 0.005 g), water for injection (up to 1 ml).

• Hypersensitivity to the components of the drug.

• Pregnancy and lactation.

• Childhood.

Dosage form : Solution for injection
The active component of the drug is a bioactive concentrate from small sea fish (Sprat (Sprattus sprattus sprattus), Black Sea Merlang (Odontogadus merlangus euxinus), Black Sea Puzonok (Alosa tanacraichus enordmanni), Black Sea Anchovy) by extraction followed by deproteinization and delipidization.

Composition :
1 ampoule with a capacity of 1 ml contains:
Active substance : bioactive concentrate 0.1 ml
Excipients : phenol (max 0.005 g), water for injection (up to 1 ml).

Description : Colorless or slightly brownish-yellow, or slightly yellow, transparent liquid.

Pharmacotherapeutic group : tissue repair stimulant of natural origin.
Pharmacological action
Alflutop is a chondroprotector, the active component of which is a bioactive concentrate from small sea fish. The concentrate contains mucopolysaccharides (chondroitin sulfate), amino acids, peptides, sodium, potassium, calcium, magnesium, iron, copper and zinc ions.
Alflutop prevents the destruction of macromolecular structures of normal tissues, stimulates recovery processes in interstitial tissue and articular cartilage tissue, which explains its analgesic effect.
The anti-inflammatory effect and tissue regeneration are based on the inhibition of the activity of hyaluronidase and the normalization of the biosynthesis of hyaluronic acid. Both of these effects are synergistic and cause the activation of regenerative processes in tissues (in particular, restoration of the cartilage structure).

Indications for use
Alflutop is used in adults with primary and secondary osteoarthritis of various localization (coxarthrosis, gonarthrosis, arthrosis of small joints), osteochondrosis and spondylosis.

Contraindications
Hypersensitivity to the components of the drug.
Pregnancy and lactation.
Childhood.

Caution
It is not recommended to prescribe the drug in adolescence due to the lack of scientific clinical data in this category of patients.

Dosage and administration In case of polyosteoarthrosis and osteochondrosis, the drug is administered deeply intramuscularly, 1 ml per day. The course of treatment is 20 injections (1 injection per day for 20 days).
With a predominant lesion of large joints, the drug is administered intra-articularly by 1-2 ml into each joint with an interval of 3-4 days. A total of 5-6 injections in each joint for a course.
A combination of intra-articular and intramuscular methods of administration is possible. It is advisable to repeat the course of treatment 6 months after consulting a doctor.

Side effects
Itching dermatitis, redness of the skin and a burning sensation at the injection site, short-term myalgias are rare. In some cases, with intra-articular injections, a transient increase in pain syndrome is possible.
Development of anaphylactic reactions is very rarely possible.

Interaction with other medicinal products
So far not identified.

Overdose
In case of an overdose in predisposed patients, allergic reactions (sometimes severe) may occur.

Special instructions
In case of individual intolerance to seafood (sea fish), the risk of developing allergic reactions increases.

Release form
Solution for injection, 1 ml in dark glass ampoules with a white break ring.
5 ampoules in a blister strip polymeric packaging without coating.
2 blisters each with instructions for use in a cardboard box.
A label is attached to each ampoule.

Storage conditions
In the dark place at a temperature of 15-25 ? C.
Keep out of the reach of children.

Shelf life is
3 years. Do not use the drug with an expired date.

Pharmacy Leave
On prescription.