Akriderm GK cream, 30 g

Simple and allergic dermatitis (especially complicated by secondary infection), diffuse neurodermatitis (including atopic dermatitis), limited neurodermatitis (including simple chronic lichen), eczema, dermatomycosis (dermatophytosis, candidiasis, versicolor versicolor), especially when localization in the groin and large folds of the skin.

Outwardly. The cream is applied to the affected skin, lightly rubbing, a small amount 2 times a day. The duration of treatment is determined individually and depends on the nosological form and severity of the disease. With dermatomycosis of the feet, the average duration of treatment is 2-4 weeks.
If clinical improvement does not occur in the near future, it is necessary to clarify the diagnosis or change the treatment regimen.

100 g of cream contain:
active substances: betamethasone dipropionate in terms of 100% substance - 0.064 g, clotrimazole in terms of 100% substance - 1 g, gentamicin sulfate in terms of gentamicin -0.1 g;
excipients: petrolatum, propylene glycol, liquid paraffin (liquid paraffin), cetostearyl alcohol [cetyl alcohol 60%, stearyl alcohol 40%]. macrogol cetostsarat (macrogol-20 cetostearyl ether), disodium edetate (Trilon B), sodium dihydrogen phosphate dihydrate (sodium phosphate monosubstituted 2-aqueous), purified water.

Hypersensitivity to any of the components of the drug, skin tuberculosis, skin manifestations of syphilis, chickenpox, herpes simplex, post-vaccination skin reactions, open wounds, children (up to 2 years).

With care
Pregnancy (especially I trimester).
Children age from 2 to 18 years old.

Trade name of the drug: Akriderm GK

International non-proprietary name or grouping name:
Betamethasone + Gentamicin + Clotrimazole

Dosage form:

cream for external use

The composition of
100 g of cream contains:
active substances: betamethasone dipropionate in terms of 100% substance - 0.064 g, clotrimazole in terms of 100% substance - 1 g, gentamicin sulfate in terms of gentamicin -0.1 g;
excipients: petrolatum, propylene glycol, liquid paraffin (liquid paraffin), cetostearyl alcohol [cetyl alcohol 60%, stearyl alcohol 40%]. macrogol cetostsarat (macrogol-20 cetostearyl ether), disodium edetate (Trilon B), sodium dihydrogen phosphate dihydrate (sodium phosphate monosubstituted 2-aqueous), purified water.

Description
White or off-white cream.

Pharmacotherapeutic group:

topical glucocorticosteroid + aminoglycoside antibiotic + antifungal agent

ATX code: D07XC01

Pharmacological properties
Pharmacodynamics The
combined preparation has anti-inflammatory, anti-allergic, antibacterial and antifungal (fungicidal) effects.
Gentamicin is a broad-spectrum antibiotic from the group of aminoglycosides, it has a bactericidal effect. Highly sensitive gram-negative microorganisms - Proteus spp. (indole positive and indole negative), Escherichia coli, Klebsiella spp., Salmonella spp .. Shigella spp., Campylobacter spp., Staphylococcus spp. (methicillin-resistant). Sensitive: Enterococcus faecalis, Serratia spp., Pseudomonas spp., Acinetobacter spp., Citrobacter spp. Resistant: Neisseria meningitidis, Treponema pallidum,anaerobic microbes: Streptococcus spp. (except Streptococcus pneumoniae), Enterococcus faecalis; Providcncia rettgeri. Betamethasone is a glucocorticosteroid that has a local anti-inflammatory, decongestant, antiallergic effect.
Clotrimazole is an antifungal agent from the group of imidazole derivatives for topical use. It acts by disrupting the synthesis of ergosterol, which is an integral part of the cell membrane of fungi. Possesses a wide spectrum of action. It is active against pathogenic dermatophytes ( Trichophyton rubrum. Trichophyton mentagrophytes, Fpidermophyton floccosum, Microsporum canis , yeast and mold fungi ( Candida spp., Torulopsis glabrata, Rhodotorula spp., Pityrosporum orbicularc ).

Pharmacokinetics
With the cutaneous application of the drug in therapeutic doses, the transdermal absorption of active substances into the blood is very insignificant. When applied to the skin, the rate of absorption of betamethasone depends on the state of the epidermal barrier (inflammation and skin diseases increase absorption). The use of occlusive dressings increases the transdermal absorption of betamethasone and gentamicin, which may lead to an increased risk of systemic side effects.

Indications for use
Simple and allergic dermatitis (especially complicated by secondary infection), diffuse neurodermatitis (including atopic dermatitis), limited neurodermatitis (including lichen simplex chronicus), eczema, dermatomycosis (dermatophytosis, candidiasis, tinea versicolor) , especially when localized in the groin area and large folds of the skin.

Contraindications
Hypersensitivity to any of the components of the drug, skin tuberculosis, skin manifestations of syphilis, chickenpox, herpes simplex, post-vaccination skin reactions, open wounds, childhood (up to 2 years).

With care
Pregnancy (especially I trimester).
Children age from 2 to 18 years old.

Application during pregnancy and lactation
During pregnancy (especially in the first trimester), topical application of the cream in pregnant women is allowed only in cases where the intended benefit to the mother outweighs the potential risk to the fetus. In such cases, the use of the drug should be short-lived and limited to small areas of the skin. It is not known whether the components of the drug are excreted in breast milk. Therefore, when prescribing Akriderm GK cream during lactation, it is recommended to stop breastfeeding.

Method of administration and dosage
Outwardly. The cream is applied to the affected areas of the skin, rubbing in a small amount, 2 times a day. The duration of treatment is determined individually and depends on the nosological form and severity of the disease. With dermatomycosis of the feet, the average duration of treatment is 2-4 weeks.
If clinical improvement does not occur in the near future, it is necessary to clarify the diagnosis or change the treatment regimen.

Side effect
Itching, burning, irritation, dry skin, folliculitis, hypertrichosis, steroid acne, hypopigmentation, allergic reactions. When using occlusive dressings - maceration, infection, skin atrophy, striae, prickly heat. With prolonged treatment or application to a large surface - the development of systemic side effects: increased body weight, osteoporosis, increased blood pressure, edema, ulceration of the mucous membrane of the gastrointestinal tract, exacerbation of hidden foci of infection, hyperglycemia, agitation, insomnia, dysmenorrhea.

Overdose
Symptoms: phenomena of hypercortisolism.
Treatment: gradual withdrawal of the drug. Symptomatic therapy. If necessary, correction of electrolyte disturbances.

Interaction with other medicinal products
Interaction of the drug with other medicinal products has not been identified.

Specific guidance
Avoid contact with eyes.
When a stable bacterial or fungal microflora appears, the drug should be canceled, and appropriate therapy should be prescribed.
Due to the fact that in children the area of ??the skin in relation to body weight is larger than in adults, and also the epidermis is insufficiently developed, with external use of the drug, absorption of a proportionally larger amount of active substances is possible and, therefore, there is a greater risk of developing systemic side effects ... The drug should be used in children as soon as possible and in compliance with all precautions.

Release form
Cream for external use.
15 or 30 g in an aluminum tube. Each tube, together with instructions for use, is placed in a cardboard box.

Storage conditions
At temperatures from 15 to 25 ? C.
Keep out of the reach of children.

Shelf life is
2 years.
Do not use after the expiration date.

Terms of dispensing from pharmacies
Without prescription.