Afrin nasal spray for rhinitis, 15 ml., Bayer
Category
Runny nose
Scope of the medicinal product
Ear, Throat, Nose
Release form
Spray
Manufacturer country
Canada
Package quantity, pcs
one
Release form, composition and packaging
?
Nasal spray 0.05% in the form of a gel-like suspension of white or almost white color, with a characteristic citrus odor.
1 ml
oxymetazoline hydrochloride 500 mcg
disodium edetate dihydrate - 300 μg, sodium hydrogen phosphate - 975 μg, sodium dihydrogen phosphate monohydrate - 5.525 mg, povidone K29-32 - 30 mg, benzalkonium chloride solution 17% - 1.471 mg, macrogol 1450 - 50 mg, benzyl alcohol - 2.5 mg, cellulose microcrystalline and sodium carmellose (avicel RC-591) - 30 mg, lemon flavoring - 1.5 mg, purified water - qs up to 1 ml.
15 ml - plastic bottles with a dosing device (1) - cardboard packs.
pharmachologic effect
Topical vasoconstrictor, alpha-adrenostimulant.
Oxymetazoline causes vasoconstriction in the mucous membranes of the nose, paranasal sinuses and the Eustachian tube, which leads to a decrease in their edema and facilitates nasal breathing in allergic and / or infectious-inflammatory rhinitis.
Due to the presence of nasal excipients in the spray (microcrystalline cellulose and sodium carmellose, povidone-K29-32), the drug does not flow out of the nose and does not drain into the throat, because
after being introduced into the nasal passages, the spray becomes more viscous and adheres to the nasal mucosa more effectively than a standard aqueous solution.
According to clinical studies, the drug begins to act within 1 minute, the effect lasts up to 12 hours.
Pharmacokinetics
When used as a nasal spray, oxymetazoline is practically not detected in blood plasma.
Indications for use
- symptomatic therapy of rhinitis of allergic and / or infectious-inflammatory etiology
- sinusitis
- eustachitis
- hay fever.
Contraindications for use
- atrophic rhinitis
- simultaneous use of MAO inhibitors (including a period of 14 days after their cancellation)
- children under 6 years of age.
- hypersensitivity to drug components.
Care should be taken to prescribe the drug for coronary artery disease, arrhythmias, chronic heart failure, severe atherosclerosis, arterial hypertension, hyperthyroidism, diabetes mellitus, chronic renal failure, angle-closure glaucoma, prostatic hyperplasia with clinical symptoms, pregnancy, lactation.
Dosage regimen
The drug is administered intranasally.
Shake the bottle vigorously before each use.
Before using the nasal spray for the first time, it must be calibrated" by pressing the spray head several times.
Adults and children over 6 years old - 2-3 injections into each nasal passage with an interval of 10-12 hours. In adults, the frequency of application can be increased up to 3 times / day.
It is not recommended to exceed the indicated dose.
Overdose
Symptoms: with a significant overdose or accidental ingestion, nausea, vomiting, cyanosis, fever, tachycardia, arrhythmia, increased blood pressure, shortness of breath, mental disorders, depression of the central nervous system (drowsiness, decreased body temperature, bradycardia, decreased blood pressure, respiratory arrest and coma) are possible.
Treatment: symptomatic
in case of accidental ingestion - gastric lavage, activated carbon.
Side effect
Local reactions: transient dryness and burning of the nasal mucosa, dry mouth and throat, sneezing.
With prolonged use - tachyphylaxis, reactive hyperemia and atrophy of the nasal mucosa.
Benzalkonium chloride, which is part of the drug, can cause irritation of the nasal mucosa.
Systemic reactions: increased blood pressure, increased anxiety, nausea, dizziness, headache, insomnia, palpitations, sleep disturbances.
Drug interactions
The drug slows down the absorption of local anesthetic drugs, lengthens the time of their action.
Combined use with other vasoconstrictor drugs
Name ENG
AFRIN
Clinical and pharmacological group
A vasoconstrictor drug for local use in ENT practice
ATX code
Oxymetazoline
Dosage
0.05% x 15ml
Structure
1 ml contains: Active ingredient: oxymetazoline hydrochloride 0.5 mg
Excipients: disodium edetate dihydrate - 300 μg, sodium hydrogen phosphate - 975 μg, sodium dihydrogen phosphate monohydrate - 5.525 mg, povidone K29-32 - 30 mg, benzalkonium chloride solution 17% - 1.471 mg, macrogol 1450 - 50 mg, benzyl alcohol - 2.5 mg, microcrystalline cellulose and sodium carmellose (Avicel RC-591) - 30 mg, lemon flavoring - 1.5 mg, purified water - qs up to 1 ml.
Indications
Symptomatic therapy of rhinitis (rhinitis) of allergic and / or infectious-inflammatory etiology
sinusitis
eustachitis
hay fever.
Storage conditions and periods
At a temperature not higher than 25 degrees.
Expiration date: 2 years
Contraindications
atrophic rhinitis
simultaneous use of MAO inhibitors (including a period of 14 days after their cancellation)
children under 6 years of age.
hypersensitivity to drug components.
Care should be taken to prescribe the drug for coronary artery disease, arrhythmias, chronic heart failure, severe atherosclerosis, arterial hypertension, hyperthyroidism, diabetes mellitus, chronic renal failure, angle-closure glaucoma, prostatic hyperplasia with clinical symptoms, pregnancy, lactation.
INN / Active ingredient
Oxymetazoline
Specifications
Category
Runny nose
Scope of the medicinal product
Ear, Throat, Nose
Release form
Spray
Manufacturer country
Canada
Package quantity, pcs
one
Scope of application
Virology
Way of introduction
Through the respiratory tract
Vacation conditions
Without recipe
Volume, ml.
15 ml
Brand name
Afrin
The amount of the dosage form in the primary package
15 ml
Primary packaging type
Dispenser bottle
Type of consumer packaging
Pack of cardboard
Pharmaco-therapeutic group
Decongestant - alpha adrenergic agonist
Anatomical and therapeutic characteristics
R01AA05 Oxymetazoline
Dosage form
Nasal spray
Expiration date in days
730
Dosage (volume) of the substance in the preparation
oxymetazoline hydrochloride - 0.5 mg.
The target audience
Adult
Package weight, g
thirty
Mode of application
:
Intranasal. < br> Before each use, shake the bottle vigorously. < br> Before the first use of the nasal spray, it is necessary to "calibrate" it by pressing the spray head several times. < br> Adults and children over 6 years old - 2-3 injections in each nasal passage with an interval of 10-12 hours. In adults, the frequency of application can be increased up to 3 times a day in adults.
It is not recommended to exceed the indicated dose.
Information on technical characteristics, delivery set, country of manufacture "