AEVIT N30 CAPs

Release form Capsules 30 pcs with instructions for use in unitary enterprise

Store in a dark place

Keep out of reach of children

Dosage form

Spherical gelatin capsules, from dark yellow to light brown in color, having a smooth surface, without damage and visible air inclusions.

Filled with an oily liquid from light yellow to dark yellow in color, without rancid odor.

Structure

Composition for one capsule:

Active ingredients:

Retinol palmitate (vitamin A) - 55 mg (100,000 ME)

Alpha-Tocopherol Acetate (Vitamin E) 100 mg

Excipients:

Corn oil - 45 mg

The mass of the contents of the capsule is 200 mg

Capsule shell:

Gelatin - 26.83 mg

Glycerol (glycerin) - 7.56 mg

Methyl parahydroxybenzoate (methylparaben) - 0.01 mg

Sorbitol (sorbitol) - 4.94 mg

Purified water - 0.65 mg

Dye Brown NT (E 155) - 0.01 mg

Capsule weight - 240 mg

general description

Multivitamin

Special conditions

To avoid the development of hypervitaminosis A and E, the recommended doses should not be exceeded.

When using the drug, one should take into account the high content of vitamin A in it (100000 IU), as well as the fact that it is a therapeutic rather than a prophylactic drug.

A diet high in selenium and sulfur-containing amino acids reduces the need for vitamin E.

Influence on the ability to drive vehicles, mechanisms

The drug does not affect the ability to drive vehicles and potentially dangerous mechanisms.

Drug interactions

Vitamin E enhances the effect of glucocorticosteroid drugs, non-steroidal anti-inflammatory drugs, increases the effectiveness and reduces the toxicity of vitamins A, D, cardiac glycosides.

Increases the effectiveness of antiepileptic drugs in patients with epilepsy (in whom the content of lipid peroxidation products in the blood is increased).

Incompatible with tetracycline antibiotics.

Salicylates and glucocorticosteroids reduce the risk of developing side effects of Aevit.

Laxatives that contain mineral oil and cholestyramine reduce the absorption of vitamins A and E.

Oral contraceptives increase the concentration of vitamin A in blood plasma.

The simultaneous use of vitamin E at a dose of more than 400 units per day with anticoagulants (coumarin and indandione derivatives) increases the risk of developing hypoprothrombinemia.

Pharmacodynamics

A combined preparation, the action of which is determined by the properties of its constituent vitamins A and E. Retinol (vitamin A) participates in the formation of visual pigments necessary for normal twilight and color vision

ensures the integrity of epithelial tissues, regulates bone growth.

Tocopherol (vitamin E) has antioxidant properties, protects unsaturated fatty acids in membranes from lipid peroxidation

participates in the formation of the intercellular substance, collagen and elastic fibers of connective tissue, vascular smooth muscles, and the digestive tract.

AEVIT restores impaired capillary blood circulation, normalizes capillary and tissue permeability, increases tissue resistance to hypoxia.

Indications

Avitaminosis A, E.

In complex therapy:

- lesions and diseases of the skin, accompanied by a violation of tissue trophism (psoriasis, some forms of eczema, ichthyosis, seborrheic dermatitis)

- obliterating endarteritis.

Contraindications

Hypersensitivity to the components of the drug, hypervitaminosis A and / or E, children under 18 years of age, pregnancy, lactation.

Carefully

Thyrotoxicosis, chronic glomerulonephritis, chronic heart failure, cholecystitis, chronic pancreatitis.

Application during pregnancy and breastfeeding

The drug is contraindicated during pregnancy and lactation.

Overdose

Symptoms of acute overdose (develop 6 hours after administration): hypervitaminosis A: in adults - drowsiness, lethargy, double vision, dizziness, severe headache, nausea, indomitable vomiting, diarrhea, irritability, bleeding gums, dryness and ulceration of the mucous membrane of the cavity mouth, peeling lips, skin (especially palms), confusion, increased intracranial pressure (in infants, hydrocephalus, protrusion of the fontanel).

Symptoms of chronic intoxication: loss of appetite, bone pain, cracks and dry skin, dryness of the oral mucosa, lips, gastralgia, vomiting, hyperthermia, asthenia, excessive fatigue, headache, photosensitivity, pollakiuria, nocturia, polyuria, irritability, hair loss , yellow-orange spots on the soles, palms, in the area of ​​the nasolabial triangle, hepatotoxic phenomena, intraocular hypertension, oligomenorrhea, portal hypertension, hemolytic anemia, changes on bone radiographs, convulsions.

Treatment: drug withdrawal

symptomatic therapy.

Symptoms of an overdose of vitamin E: when taken for a long period at doses of 400-800 units per day - blurred vision, dizziness, headache, nausea, diarrhea, gastralgia, asthenia

when taking more than 800 units per day for a long period - an increased risk of bleeding in patients with hypovitaminosis K, impaired metabolism of thyroid hormones, sexual dysfunction, thrombophlebitis, necrotizing colitis, sepsis, hepatomegaly, hemorrhagic stroke, ascites.

Treatment: drug withdrawal, symptomatic therapy.

Side effects

Possibly: allergic reactions (including skin rash), pain in the epigastric region, dyspeptic disorders (nausea, vomiting, diarrhea).

With prolonged use in large doses, exacerbation of cholelithiasis and chronic pancreatitis is possible

Local reactions: with intramuscular injection - soreness, infiltration, calcification of soft tissues.

Dosage

100mg + 55mg

Indications

Hypo- and avitaminosis A and E, as well as states of increased body demand for vitamins A and E and / or a decrease in their intake into the body: gastrectomy, diarrhea, steatorrhea, celiac disease, Crohn's disease, malabsorption syndrome, chronic cholestasis, liver cirrhosis, biliary atresia pathways, obstructive jaundice, cystic fibrosis of the pancreas, tropical sprue, infectious diseases (including chronic and colds"), hemeralopia, xerophthalmia, keratomalacia, inadequate and unbalanced nutrition (including parenteral nutrition), rapid weight loss , nicotine addiction, drug addiction, alcoholism, prolonged stress, taking cholestyramine, colestipol, mineral oils, neomycin, iron-containing products, when prescribing a diet with a high content of polyunsaturated fatty acids, hyperthyroidism, pregnancy (incl.multiple), lactation period.

Peripheral neuropathy, necrotizing myopathy, abetalipoproteinemia.

Efficiency has not been proven - atherosclerotic changes in blood vessels, tissue trophism disorders, obliterating endarteritis.

Contraindications

Hypersensitivity, hypervitaminosis A and E, children (up to 14 years old).

With care: thyrotoxicosis, cholecystitis, conditions accompanied by increased vascular permeability (CHF, chronic glomerulonephritis, etc.), cirrhosis of the liver, viral hepatitis, renal failure, alcoholism, pregnancy (especially the first trimester), lactation, advanced age, childhood, hypoprothrombinemia (against the background of vitamin K deficiency - it can increase with a dose of vitamin E over 400 IU).

INN / Active ingredient

Retinol palmitate + alpha-tocopherol acetate

Storage conditions and periods

In a dark place at a temperature not exceeding 25 degrees.

Expiration date: 2 years

Specifications

Category

Vitamin and mineral complexes

Scope of the drug

Vitamins

Release form

Capsules

Manufacturer country

Russia

Package quantity, pcs

thirty

Vacation conditions

Without recipe

Brand name

Aevit

The amount of the dosage form in the primary package

10 pieces.

Primary packaging type

Blister

Type of consumer packaging

Pack of cardboard

Pharmaco-therapeutic group

Multivitamin

Anatomical and therapeutic characteristics

A11JA Vitamins in combination

Dosage form

Capsules

Expiration date in days

730

Package weight, g

15

Dosage (volume) of the substance in the preparation

:

β-tocopherol acetate 100 mg, retinol acetate (or retinol palmitate) 100,000 IU

Information on technical characteristics, delivery set, country of manufacture "