adapalene | Differin gel for external use 0, 1% 30 g

Release form

Gel

Packing

Tube 30 g.

Pharmacological action

Adapalen represents a new generation of synthetic retinoids and is a derivative of naphthoic acid.

Adapalen has a sebostatic, comedonolytic / anti-comedogenic and anti-inflammatory effect.

The drug acts on follicular hyperkeratosis, regulating the process of keratinization and desquamation - it has a pronounced comedonolytic activity (affects open and closed comedones) and an anti-comedogenic effect (prevents the formation of micro comedones).

The main mechanism of action is the selective binding of epidermal cells to nuclear RAg receptors in contrast to the indiscriminate binding of retinoids of previous generations.

This mechanism regulates the final differentiation of keratinocytes, which ensures the normalization of the keratinization process and a decrease in the prerequisites for the formation of micro comedones.

The pronounced anti-inflammatory effect of adapalene is proved: inhibition of lipoxygenase, arichidonic acid, cytokines. Adapalene does not have a photosensitizing effect.

Indications

Acne.

Contraindications

Hypersensitivity to the drug, pregnancy, lactation.

Caution: dermatitis, seborrhea, eczema.

Special instructions

When using the drug, avoid contact with eyes and lips.

In some cases, when the drug is used, short-term skin irritation is possible, in such cases, therapy can be interrupted until the signs of irritation disappear.

During the period of use of the drug, active exposure to the sun and UV radiation should be avoided due to possible slight skin irritation.

During the period of use of the drug, it is not recommended to use cosmetic products with a drying or irritating effect (including perfumes, ethanol-containing products).

It is possible to use other agents to treat acne while using Differin, while Differin is used 1 time / day before bedtime, and in the morning other drugs are used (for example, 4% erythromycin lotion, 1% clindamycin lotion, water-based benzoyl peroxide in a concentration not exceeding 10%).

The simultaneous use of makeup products and moisturizers that do not contribute to the formation of comedones.

Composition

1 g contains 1 mg adapalene.

Dosage and administration

Differin is applied evenly, without rubbing, to the affected skin 1 time / day before bedtime. The drug should be applied to clean, dry skin. The therapeutic effect develops after 4-8 weeks of therapy, persistent improvement - after 3 months from the start of therapy. It is possible to conduct repeated courses of therapy with the drug on the recommendation of a doctor.

Differin cream is recommended for sensitive and dry skin. Differin is indicated for the treatment of mild to moderate acne as a monotherapy, and for moderate acne also in combination with other local (antibiotics, benzoyl peroxide) and systemic (antibiotics, antiandrogens for oral administration) drugs.

Side effects

Local reactions: when applying the cream in excessive amounts, redness and peeling of the skin is possible.

Drug Interactions

No clinically significant drug interactions of Differin have been established with the use of clindamycin phosphate or benzoyl peroxide.

Possible simultaneous administration with clindamycin or benzoyl peroxide.

Storage conditions

Store at a temperature not exceeding 25 РC, out of the reach of children.

Deystvuyuschee substances

adapalene

Terms and conditions

without prescription

Indications

Ugrevaya s py