Paroxetine | adepress tablets are covered.ob. 20 mg, 30 pcs.

Special Price $20.24 Regular Price $31.00
In stock
SKU
BID464450
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Release form

Coated tablets
Release form

Coated tablets

Packing

30 pcs.

Pharmacological action

Adepress - antidepressant. It is a selective inhibitor of serotonin reuptake (5-hydroxytryptamine, 5-HT) by brain neurons, which determines its antidepressant effect and effectiveness in the treatment of obsessive-compulsive (OCD) and panic disorder.

Paroxetine has a low affinity for m-cholinergic receptors (has a weak anticholinergic effect), 1-, 2- and -adrenoreceptors, as well as dopamine (D2), 5HT1-like, 5HT2-like and histamine H1 receptors.

Paroxetine does not violate psychomotor functions and does not potentiate the inhibitory effect of ethanol on them.

According to a study of behavior and EEG in paroxetine, weak activating properties are detected when it is prescribed in doses higher than those necessary to inhibit serotonin uptake. In healthy volunteers, it does not cause a significant change in the level of blood pressure, heart rate and EEG.

Indications

Depression of all types, including reactive, severe endogenous depression and anxiety depression

Obsessive-compulsive disorder (OCD)

Panic disorder, including with fear of being in the crowd (agoraphobia)

Social anxiety disorder / social phobia

Generalized anxiety disorder

Post-traumatic stress disorder.

Contraindications

Concomitant use of MAO inhibitors and the period of 14 days after their withdrawal

Unstable epilepsy

Pregnancy and lactation (breastfeeding)

Childhood

Hypersensitivity to the components of the drug.

Precautions: in case of liver failure, renal failure, angle-closure glaucoma, prostatic hyperplasia, mania, heart pathology, epilepsy, convulsive conditions, the simultaneous administration of electric pulse therapy, the simultaneous administration of drugs that increase the risk of bleeding, the presence of risk factors for increased bleeding and diseases that increase risk of bleeding, as well as elderly patients.

Special instructions

Adepress should be prescribed to patients taking antipsychotics with caution in order to avoid the development of malignant antipsychotic syndrome.

In elderly patients, while taking Adepress, hyponatremia is possible.

In some cases, dose adjustment of the simultaneously used insulin and / or oral hypoglycemic drugs is required.

With the development of seizures, treatment with Adepress is discontinued.

At the first sign of mania, the drug should be discontinued.

During the first few weeks of adepress therapy, the patient should be closely monitored for possible suicidal attempts.

During therapy with Adepress, one should refrain from drinking alcohol in connection with an increase in its toxic effect.

Influence on the ability to drive vehicles and control mechanisms

Despite the fact that paroxetine does not impair cognitive and psychomotor functions, patients should abstain or exercise extreme caution when driving and when engaging in other potentially dangerous activities that require increased concentration and speed of psychomotor reactions.

Dosing and Administration

Addepress Tablets should be taken 1 time / day, in the morning, with meals, without chewing, washed down with water.

Dose is selected individually during the first 2-3 weeks after the start of therapy and subsequently adjusted if necessary. The effect in most cases develops gradually. The dose should be increased by 10 mg every week until a therapeutic effect is achieved. The maximum daily dose should not exceed 60 mg / day.

For renal and / or liver failure, the recommended dose is 20 mg / day.

For elderly patients, the daily dose should not exceed 40 mg.

Supportive therapy is needed to prevent relapse. After the symptoms of depression disappear, this course can be 4-6 months, and with obsessive and panic disorders - more than 4-6 months.

Avoid abrupt discontinuation of the drug. In order to prevent the development of withdrawal syndrome, discontinuation of the drug Adepress should be carried out gradually.

Side effects

From the central nervous system and peripheral nervous system: often drowsiness or insomnia, tremors, asthenia, dizziness, anxiety sometimes - confusion, hallucinations, extrapyramidal disorders, paresthesias, decreased ability to concentrate rarely - cramps, mania very rarely - serotonin syndrome (agitation, hyperreflexia, diarrhea), panic disorders.

On the part of the sensory organs: in some cases - visual impairment, mydriasis.

From the musculoskeletal system: rarely - myasthenia gravis, myoclonia, arthralgia, myalgia.

From the urinary system: frequent urination rarely - urinary retention.

From the reproductive system: ejaculation disorders, rarely libido disorders - hyperprolactinemia / galactorrhea, anorgasmia.

From the digestive system: loss of appetite, nausea, vomiting, dry mouth sometimes - constipation or diarrhea in some cases - hepatitis.

From the cardiovascular system: orthostatic hypotension.

Allergic reactions: rarely - rash, urticaria, ecchymosis, pruritus, angioedema.

Other: increased sweating in isolated cases - hyponatremia, impaired secretion of antidiuretic hormone.

Storage conditions

Store in a dry place inaccessible to children at a temperature not exceeding 25 РC.

Expiration

2 years.

Deystvuyuschee substances

Paroxetine

Conditions condiment from

pharmacies Prescription

dosage form

tablets

Appointment

Vzrosl m in naznacheniyu Vracha

Indications

Stress, phobia and panycheskye attack

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