hesperidin, Diosmin | Detralex tablets 500 mg, 60 pcs.

packaging 60 pcs

Pharmacological action

Detralex® has venotonic and angioprotective properties.

The drug reduces the extensibility of veins and venous congestion, reduces the permeability of capillaries and increases their resistance. The results of clinical studies confirm the pharmacological activity of the drug in relation to venous hemodynamics.

The statistically significant dose-dependent effect of Detralex® was demonstrated for the following venous plethysmographic parameters: venous capacity, venous extensibility, time of venous emptying. The optimal dose / effect ratio is observed when taking 2 tablets.

Detralex® improves venous tone: venous occlusion plethysmography has been shown to decrease venous emptying time. In patients with signs of severe microcirculatory dysfunction (statistically significant), compared with placebo, an increase in capillary resistance, evaluated by angiostereometry, after therapy with Detralex®, is noted.

The therapeutic efficacy of Detralex® has been proven in the treatment of chronic lower extremity vein diseases, as well as in the treatment of hemorrhoids.

Pharmacokinetics

The main excretion of the drug occurs with feces. With urine, on average, about 14% of the accepted amount of the drug is excreted.

T1 / 2 is 11 hours.

The drug undergoes active metabolism, as evidenced by the presence of phenolic acids in the urine.

Indications

Symptomatic therapy of venous-lymphatic insufficiency, a feeling of heaviness in the legs, pain, Morning leg fatigue, cramps, trophic disorders, symptomatic therapy of exacerbation of hemorrhoids.

Contraindications

Hypersensitivity to the components of the drug.

Pregnancy and lactation

Pregnancy

Animal experiments have not revealed teratogenic effects.

To date, there have been no reports of any side effects when using the drug in pregnant women.

Breastfeeding

Due to a lack of data regarding the excretion of the drug in breast milk, lactation is not recommended for women.

Composition

1 tablet contains:

Active ves Society:

purified micronized flavonoid fraction 500 mg (including diosmin (90%) 450 mg,

flavonoids expressed as hesperidin (10%) 50 mg).

Excipients:

gelatin,

magnesium stearate,

microcrystalline cellulose,

sodium starch glycolate,

talc,

glycerol,

srclklrd (red iron oxide s17lkpr2kpr2),

r2 krp2 titanium dioxide (E171),

sodium lauryl sulfate.

Dosage and administration of

The drug is taken orally.

The recommended dose is 2 tablets per day, 1 tablet in the middle of the day and 1 tablet in the evening with meals.

During an exacerbation of hemorrhoids - 6 tablets per day for 4 days, then 4 tablets per day for the next 3 days.

Side effects of

From the central nervous system: rarely - dizziness, headache, general malaise.

From the gastrointestinal tract: often - diarrhea, dyspepsia, nausea, vomiting infrequently - colitis.

From the skin: rarely - rash, itching, urticaria of unspecified frequency - isolated swelling of the face, lips, eyelids. In exceptional cases, angioedema.

Storage conditions

The product should be stored out of the reach of children at a temperature not exceeding 30 РC.

Term hodnosty

4 years

lekarstvennaja form

tablets

Prescribing

Adults as prescribed by the doctor, Pregnant as prescribed by the doctor

Indications

Indications

Varicosity, trophic ulcers, hemorrhoids

Servier / Serdiks, Russia