diosmin | Phlebodia 600 tablets 600 mg, 30 pcs.
Special Price
$33.95
Regular Price
$42.00
In stock
SKU
BID463484
Latin name
Flebodia 600
Flebodia 600
Latin name
Flebodia 600
packaging 30 pcs
Pharmacological action of
The preparation Phlebodia 600 has phlebotonizing effect (reduces venous extensibility, increases venous tone (dose-dependent effect), reduces venous congestion), improves lymphatic drainage (increases the tone and frequency of reduction of lymphatic capillaries, increases their functional density, reduces lymphatic pressure), improves microcirculation (increases capillary resistance (dose-dependent effect), reduces their permeability), reduces the adhesion of leukocytes to the venous wall and their migration into paravenous tissues, improves oxygen diffusion and perfusion in the skin tissue, and has anti-inflammatory effects. Enhances the vasoconstrictor effect of adrenaline, norepinephrine, blocks the production of free radicals, the synthesis of prostaglandins and thromboxane.
Pharmacokinetics
Quickly absorbed from the gastrointestinal tract, detected in plasma 2 hours after administration. The maximum plasma concentration is reached 5 hours after administration. Evenly distributed and accumulated in all layers of the walls of the vena cava and saphenous veins of the lower extremities, to a lesser extent - in the kidneys, liver and lungs and other tissues. The selective accumulation of diosmin and / or its metabolites in the venous vessels reaches a maximum by 9 hours after administration and persists for 96 hours. It is excreted by the kidneys 79%, intestines - 11%, with bile - 2.4%.
Indications
As part of complex therapy: elimination of symptoms of lymphovenous insufficiency of the lower extremities: feeling of heaviness or tiredness in the legs, pain
additional treatment for violation of microcirculation
acute hemorrhoids (symptomatic therapy).
Contraindications
hypersensitivity to the components of the drug Phlebodia 600
breastfeeding period
pregnancy (I trimester - experience with use is limited)
childhood (under 18 years).
Use during pregnancy and lactation
Until now, in clinical practice there have been no reports of any side effects when using the drug in pregnant women. The use during pregnancy in the II and III
trimesters is possible only as prescribed by the doctor in cases where the expected benefit to the mother outweighs the potential risk to the fetus.
In experimental studies, no teratogenic effects on the fetus were detected. During breastfeeding, it is not recommended to take the drug, because there is no data on the penetration of the drug into breast milk.
Composition
1 tablet contains:
Active ingredient: diosmin (in terms of dry matter) 600 mg
Excipients: talc - 10.24 mg of silicon colloidal dioxide - 3.5 mg of stearic acid - 50.05 mg MCC - to 910 mg
film sheath: Sepifilm 002 (hypromellose (E464) - 9.832 mg, MCC - 7.866 mg, macrogol 8 stearate type 1 - 1.967 mg) Sepispers AR 5523 pink (propylene glycol - traces, hypromellose (E464) - 0.458 mg, titanium dioxide (E171) - 4.026 mg , crimson dye [Ponceau 4R] (E124) - 0.401 mg, black iron oxide (E172) - 0.13 mg, red iron oxide (E172) - 0.02 mg) Opaglos 6000 (carnauba wax (E903) - 0.075 mg, beeswax (E901) - 0.075 mg, shellac (E904) - 0.15 mg, ethanol 95 ° - traces).
Dosage and administration of
Before using the drug, consult your doctor.
The drug is intended for oral administration.
With varicose veins of the lower extremities and chronic lymphovenous insufficiency (edema, pain, cramps), I tablet is prescribed per day in the morning on an empty stomach. The duration of therapy is usually 2 months. With exacerbation of hemorrhoids, the drug is prescribed for 2-3 tablets per day with meals for 7 days. If one or more doses of the drug is missed, it is necessary to continue the use of the drug in the usual mode and in the usual dose.
Side effects
In rare cases, hypersensitivity to the components of the drug (requiring a break in treatment).
From the gastrointestinal tract: dyspeptic disorders (heartburn, nausea, abdominal pain).
From the side of the central nervous system: headache.
If any of the side effects listed in the description are exacerbated, or the patient has noticed any other side effects not listed in the description, you should inform your doctor.
Storage conditions
Do not store above 30 РC.
Shelf life
3 years.
dosage form
tablets
Laboratory of Innoter, France
Flebodia 600
packaging 30 pcs
Pharmacological action of
The preparation Phlebodia 600 has phlebotonizing effect (reduces venous extensibility, increases venous tone (dose-dependent effect), reduces venous congestion), improves lymphatic drainage (increases the tone and frequency of reduction of lymphatic capillaries, increases their functional density, reduces lymphatic pressure), improves microcirculation (increases capillary resistance (dose-dependent effect), reduces their permeability), reduces the adhesion of leukocytes to the venous wall and their migration into paravenous tissues, improves oxygen diffusion and perfusion in the skin tissue, and has anti-inflammatory effects. Enhances the vasoconstrictor effect of adrenaline, norepinephrine, blocks the production of free radicals, the synthesis of prostaglandins and thromboxane.
Pharmacokinetics
Quickly absorbed from the gastrointestinal tract, detected in plasma 2 hours after administration. The maximum plasma concentration is reached 5 hours after administration. Evenly distributed and accumulated in all layers of the walls of the vena cava and saphenous veins of the lower extremities, to a lesser extent - in the kidneys, liver and lungs and other tissues. The selective accumulation of diosmin and / or its metabolites in the venous vessels reaches a maximum by 9 hours after administration and persists for 96 hours. It is excreted by the kidneys 79%, intestines - 11%, with bile - 2.4%.
Indications
As part of complex therapy: elimination of symptoms of lymphovenous insufficiency of the lower extremities: feeling of heaviness or tiredness in the legs, pain
additional treatment for violation of microcirculation
acute hemorrhoids (symptomatic therapy).
Contraindications
hypersensitivity to the components of the drug Phlebodia 600
breastfeeding period
pregnancy (I trimester - experience with use is limited)
childhood (under 18 years).
Use during pregnancy and lactation
Until now, in clinical practice there have been no reports of any side effects when using the drug in pregnant women. The use during pregnancy in the II and III
trimesters is possible only as prescribed by the doctor in cases where the expected benefit to the mother outweighs the potential risk to the fetus.
In experimental studies, no teratogenic effects on the fetus were detected. During breastfeeding, it is not recommended to take the drug, because there is no data on the penetration of the drug into breast milk.
Composition
1 tablet contains:
Active ingredient: diosmin (in terms of dry matter) 600 mg
Excipients: talc - 10.24 mg of silicon colloidal dioxide - 3.5 mg of stearic acid - 50.05 mg MCC - to 910 mg
film sheath: Sepifilm 002 (hypromellose (E464) - 9.832 mg, MCC - 7.866 mg, macrogol 8 stearate type 1 - 1.967 mg) Sepispers AR 5523 pink (propylene glycol - traces, hypromellose (E464) - 0.458 mg, titanium dioxide (E171) - 4.026 mg , crimson dye [Ponceau 4R] (E124) - 0.401 mg, black iron oxide (E172) - 0.13 mg, red iron oxide (E172) - 0.02 mg) Opaglos 6000 (carnauba wax (E903) - 0.075 mg, beeswax (E901) - 0.075 mg, shellac (E904) - 0.15 mg, ethanol 95 ° - traces).
Dosage and administration of
Before using the drug, consult your doctor.
The drug is intended for oral administration.
With varicose veins of the lower extremities and chronic lymphovenous insufficiency (edema, pain, cramps), I tablet is prescribed per day in the morning on an empty stomach. The duration of therapy is usually 2 months. With exacerbation of hemorrhoids, the drug is prescribed for 2-3 tablets per day with meals for 7 days. If one or more doses of the drug is missed, it is necessary to continue the use of the drug in the usual mode and in the usual dose.
Side effects
In rare cases, hypersensitivity to the components of the drug (requiring a break in treatment).
From the gastrointestinal tract: dyspeptic disorders (heartburn, nausea, abdominal pain).
From the side of the central nervous system: headache.
If any of the side effects listed in the description are exacerbated, or the patient has noticed any other side effects not listed in the description, you should inform your doctor.
Storage conditions
Do not store above 30 РC.
Shelf life
3 years.
dosage form
tablets
Laboratory of Innoter, France
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