chelovecheskyy recombinant interferon | Ingaron lyophilisate d / pr.r-ra for v / mouse and v / mouse and subcutaneous injection. 100 thousand ME bottle 5 pcs.
Special Price
$41.40
Regular Price
$54.00
In stock
SKU
BID465461
Latin name
Ingaron
Ingaron
Latin name
Ingaron
Release form
Lyophilisate for preparation of solution for subcutaneous and intramuscular administration
Packing
5 bottles of
Pharmacological action
Pharmacotherapeutic group
Immunomodulating agent.
ATX code [LO3AB03]
Pharmacological properties of
INGARON® - recombinant human gamma interferon, consists of 144 amino acid residues (aa), is devoid of the first three a. about. Cys-tyr-cys, replaced by Met. The molecular weight is 16.9 kDa. Obtained by microbiological synthesis in a recombinant strain of Escherichia coli and purified by column chromatography. The specific antiviral activity on the cells (human fibroblasts) infected with the virus of vesicular stomatitis is 2 · 107 PIECES per mg of protein. Interferon gamma (immune interferon) is the most important anti-inflammatory cytokine, the producers of which in the human body are natural killer cells, CD4 Th1 cells and CD8 cytotoxic suppressor cells.
Interferon gamma receptors have macrophages, neutrophils, natural killer cells, cytotoxic T-lymphocytes. It activates the effector functions of these cells, in particular their microbicidal activity, cytotoxicity, their production of cytokines, superoxide and nitrooxide radicals (thereby causing the death of intracellular parasites). Interferon gamma blocks the replication of viral DNA and RNA, the synthesis of viral proteins and the assembly of mature viral particles. In this case, it causes a cytotoxic effect on virus-infected cells.
Inhibits the B-cell response to interleukin-4, inhibits the production of IgE and the expression of CB23 antigen. It is an inducer of apoptosis of differentiated B cells, giving rise to autoreactive clones. It cancels the suppressive effect of interleukin-4 on interleukin-2-dependent proliferation and the generation of lymphokines of activated killers. It activates the production of proteins of the acute phase of inflammation, enhances the expression of genes C2 and C4 of the components of the complement system.
Unlike other interferons, it increases the expression of MHC antigens of both the first and second classes on different cells, and induces the expression of these molecules even on those cells that do not express them constitutively. This increases the efficiency of the presentation of antigens and the ability of their recognition by T-lymphocytes.
interferon gamma blocks synthesis –TGF, responsible for the development of lung and liver fibrosis.
Indications
Prevention and treatment (as part of complex therapy) of influenza. Prevention and treatment (as part of complex therapy) of H5N1 and H1N1 flu.
Contraindications
Individual intolerance to interferon gamma or any other component of the drug. Pregnancy. Children's age (under 7 years).
Use during pregnancy and lactation
Contraindicated in pregnancy.
Composition
Ak gamma ֱ00 000 IU (5.5 Ѡ0.5).
Excipients: mannitol
Description
The preparation is a loose or porous mass of white color, hygroscopic.
Dosage and Administration
Intranasally. The contents of the vial are dissolved in 5 ml of water for injection.
At the first sign of influenza, SARS 2 drops in each nasal passage after toilet nasal passages 5 times a day for 5 to 7 days.
For the prevention of acute respiratory viral infections and influenza in contact with the patient and / or during hypothermia
2 - 3 drops in each nasal passage every other day 30 minutes before breakfast for 10 days.
If necessary, repeat the preventive courses. With a single contact, one instillation is enough.
After instillation, it is recommended to massage the wings of the nose with your fingers for several minutes to evenly distribute the drug in the nasal cavity.
Side effects
Not observed.
Storage conditions
In a dry, dark place and out of the reach of children, at a temperature not exceeding + 25 РC.
Store the drug solution for no more than 10 days in the refrigerator (do not freeze).
Expiration
2 years.
Active ingredient
Interferon gamma human recombinant
pharmacy terms with prescription
Le drug form
solution for injection
Indications
genital herpes, hepatitis infection mochev vodyaschyh tracks, HIV-infection, HPV, chlamydia
Farmaklon, Russia
Ingaron
Release form
Lyophilisate for preparation of solution for subcutaneous and intramuscular administration
Packing
5 bottles of
Pharmacological action
Pharmacotherapeutic group
Immunomodulating agent.
ATX code [LO3AB03]
Pharmacological properties of
INGARON® - recombinant human gamma interferon, consists of 144 amino acid residues (aa), is devoid of the first three a. about. Cys-tyr-cys, replaced by Met. The molecular weight is 16.9 kDa. Obtained by microbiological synthesis in a recombinant strain of Escherichia coli and purified by column chromatography. The specific antiviral activity on the cells (human fibroblasts) infected with the virus of vesicular stomatitis is 2 · 107 PIECES per mg of protein. Interferon gamma (immune interferon) is the most important anti-inflammatory cytokine, the producers of which in the human body are natural killer cells, CD4 Th1 cells and CD8 cytotoxic suppressor cells.
Interferon gamma receptors have macrophages, neutrophils, natural killer cells, cytotoxic T-lymphocytes. It activates the effector functions of these cells, in particular their microbicidal activity, cytotoxicity, their production of cytokines, superoxide and nitrooxide radicals (thereby causing the death of intracellular parasites). Interferon gamma blocks the replication of viral DNA and RNA, the synthesis of viral proteins and the assembly of mature viral particles. In this case, it causes a cytotoxic effect on virus-infected cells.
Inhibits the B-cell response to interleukin-4, inhibits the production of IgE and the expression of CB23 antigen. It is an inducer of apoptosis of differentiated B cells, giving rise to autoreactive clones. It cancels the suppressive effect of interleukin-4 on interleukin-2-dependent proliferation and the generation of lymphokines of activated killers. It activates the production of proteins of the acute phase of inflammation, enhances the expression of genes C2 and C4 of the components of the complement system.
Unlike other interferons, it increases the expression of MHC antigens of both the first and second classes on different cells, and induces the expression of these molecules even on those cells that do not express them constitutively. This increases the efficiency of the presentation of antigens and the ability of their recognition by T-lymphocytes.
interferon gamma blocks synthesis –TGF, responsible for the development of lung and liver fibrosis.
Indications
Prevention and treatment (as part of complex therapy) of influenza. Prevention and treatment (as part of complex therapy) of H5N1 and H1N1 flu.
Contraindications
Individual intolerance to interferon gamma or any other component of the drug. Pregnancy. Children's age (under 7 years).
Use during pregnancy and lactation
Contraindicated in pregnancy.
Composition
Ak gamma ֱ00 000 IU (5.5 Ѡ0.5).
Excipients: mannitol
Description
The preparation is a loose or porous mass of white color, hygroscopic.
Dosage and Administration
Intranasally. The contents of the vial are dissolved in 5 ml of water for injection.
At the first sign of influenza, SARS 2 drops in each nasal passage after toilet nasal passages 5 times a day for 5 to 7 days.
For the prevention of acute respiratory viral infections and influenza in contact with the patient and / or during hypothermia
2 - 3 drops in each nasal passage every other day 30 minutes before breakfast for 10 days.
If necessary, repeat the preventive courses. With a single contact, one instillation is enough.
After instillation, it is recommended to massage the wings of the nose with your fingers for several minutes to evenly distribute the drug in the nasal cavity.
Side effects
Not observed.
Storage conditions
In a dry, dark place and out of the reach of children, at a temperature not exceeding + 25 РC.
Store the drug solution for no more than 10 days in the refrigerator (do not freeze).
Expiration
2 years.
Active ingredient
Interferon gamma human recombinant
pharmacy terms with prescription
Le drug form
solution for injection
Indications
genital herpes, hepatitis infection mochev vodyaschyh tracks, HIV-infection, HPV, chlamydia
Farmaklon, Russia
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