Albendazole | Nemozole tablets 400 mg, 1 pc.

release form

tablets

Packing

1 pc

Pharmacological action

Albendazole is an anthelmintic drug whose pharmacological properties are due to the action of the active substance albendazole. Albendazole belongs to the carbamatebenzimidazole group. The mechanism of action of albendazole is its ability to disrupt the activity of the microtubular system of the cells of the intestinal channel of helminths, causing damage to the tubulin protein.

The consequence of this is biochemical disturbances in the cell - inhibition of glucose transport and fumarate reductose, which underlies the suppression of cell division at the metaphase stage and which is associated with inhibition of egg laying and the development of helminth larvae. Albendazole blocks the movement of secretory granules and other organelles in the muscle cells of roundworms, causing their death.

Albendazole is effective against most intestinal nematodes, as well as the larval (larval stages) of cestodes, as well as lamblia. Albendazole as an antiparasitic drug has a fairly wide spectrum of action.

Pharmacokinetics

Absorption. After oral administration, the drug is poorly absorbed in the gastrointestinal tract, unchanged is not determined in blood plasma. Oral bioavailability is low. Eating fatty foods increases absorption and maximum concentration by 5 times.

Metabolism. Albendazole is rapidly converted in the liver to the primary metabolite of β-albendazole sulfoxide, which also has anthelmintic activity.

distribution. The maximum plasma concentration of albendazole sulfoxide is achieved 2-5 hours after administration. 70% of the metabolite is associated with plasma proteins and is completely distributed throughout the body: it is found in urine, bile, liver, in the wall and fluid of helminth cysts, cerebrospinal fluid.

Withdrawal. Albendazole sulfoxide in the liver is converted to albendazole sulfone (a secondary metabolite) and other oxidized products. The elimination half-life of albendazole sulfoxide is 8-12 hours. It is excreted through the kidneys in the form of various metabolites. Excretion through the kidneys of albendazole and albendazole sulfoxide is negligible. In patients with impaired renal function, clearance does not change.

In patients with liver damage, bioavailability increases, the maximum concentration of albendazole sulfoxide in blood plasma increases by 2 times, and the half-life is extended.

Albendazole induces cytochrome CUR1A2 in human liver cells, accelerates the metabolism of many drugs.

Indications

Nematoses (ascariasis, enterobiosis, hookworm infection, necatorosis, trichocephalosis)

mixed helminthic invasions

strongyloidiasis

neurocysticercosis, larval larva, larval form of larva, Ta caused by the larval form of Echinococcus granulosus

giardiasis

toxocariasis

as an aid in the surgical treatment of echinococcosis cysts.

Contraindications

- Hypersensitivity to albendazole, other components of the drug and other benzimidazole derivatives

- retinal pathology

- children under 3 years of age (for this dosage form)

- pregnancy and the period of breastfeeding

Precautions

The drug albendazole is used with caution in case of impaired liver function (necessary before and during time of treatment to regularly monitor liver function), inhibition of bone marrow hematopoiesis, cirrhosis.

Use during pregnancy and lactation

The drug albendazole is contraindicated in pregnancy and during breastfeeding.

Ingredients

1 tablet contains:

Active ingredient: albendazole 400 mg

Excipients: corn starch, sodium lauryl sulfate, povidone-30, methyl paraben, propyl paraben, gelatin, purified talc, starch starch, sodium starch starch shells: hydroxypropylmethyl cellulose, titanium dioxide, propylene glycol isopropanol, methylene chloride (evaporate during drying).

Dosage and Administration

Inside, during or after a meal. Special training and diet are not required. The dosage form is selected individually, depending on the convenience of taking the drug and the tolerability of its constituent substances.

The dose of the drug is set individually, depending on the type of invasion and the patient’s body weight.

The maximum daily dose is 800 mg.

In children, whenever possible, avoid the use of high doses of albendazole for a long time.

For nematodoses (including ascariasis, trichocephalosis, necatorosis)

The standard dose for treating roundworm infestations for adults and children weighing 60 kg or more is 400 mg per day once

for adults and children weighing less than 60 kg -15 mg / kg body weight once or in 2 divided doses.

With enterobiasis, adults and children over 3 years of age take the drug at a dose of 400 mg once. If necessary, after 14 days, repeat the treatment in the same dose and in the same mode.

In case of strongyloidosis, hookworm, adults and children over 3 years old take the drug in a dose of 400 mg once for 3 days. If necessary, after 7 days, repeat the treatment in the same doses.

With trichinosis, the drug is taken 400 mg 2 times a day for 10-14 days. With severe invasion and organ damage (myocarditis, pneumonitis, meningoencephalitis), glucocorticosteroid and symptomatic agents are also taken.

For toxocariasis, adults and children over 14 years of age and weighing more than 60 kg take 400 mg 2 times a day for 10 days, with a body weight of less than 60 kg 200 mg. Repeated courses of treatment are required at intervals of 2 weeks / month. In the process of treatment, control of peripheral blood (once every 5-7 days) and aminotransferases is necessary at the same time.

With giardiasis: 400 mg 1 time per day for 3 days. Children weighing less than 10 kg -200 mg once a day once for 5 days.

With mixed invasions, the drug is taken 400 mg 2 times a day, for 3 days. If necessary, the course of treatment can be repeated after 1 month.

With neurocysticercosis and hydatidosis echinoccosis, patients with a body weight of 60 kg or more should take 400 mg 2 times a day, with a body weight of less than 60 kg - based on 15 mg / kg of body weight per day in 2 divided doses, the maximum daily dose is 800 mg. The course of treatment for neurocysticercosis is 28-30 days (2 days before taking the drug and in the first week of taking glucocorticosteroid drugs), with echinococcosis - 3 cycles of 28 days with a 14 day break between cycles.

Before using the drug, a clinical blood test and a biochemical blood test are necessary. Treatment is carried out with normal laboratory parameters. In the process of treatment, a blood and aminotransferase test is carried out every 5-7 days.

With a decrease in white blood cells below 3, 0x109 and a 2-fold increase in the activity of aminotransferases, it is necessary to suspend treatment until normal indicators.

Therapy with the drug can be resumed after the laboratory parameters return to the level that was before the start of therapy, however, during the laboratory tests should be carried out regularly.

The appointment of hepatoprotectors during treatment and in cases of toxic manifestations is ineffective, drug withdrawal is necessary.

Treatment with albendazole alveolar echinococcosis is an additional treatment.

Doses and regimen of the drug are the same as with hydatidosis echinococcosis. The duration and course of treatment is determined by the patient's condition and tolerance to the drug.

Side effects of the

From the digestive system: impaired liver function with a change in liver function tests (mild or moderate increase in transaminase activity), abdominal pain, nausea, vomiting.

From the hemopoietic system: leukopenia, granulocytopenia, agranulocytosis, thrombocytopenia, pancytopenia.

From the side of the central nervous system: headache, dizziness, meningeal symptoms.

Dermatological reactions: reversible alopecia, skin rash, itching.

Other: fever, increased blood pressure, acute renal failure, allergic reactions.

Drug Interaction

Concomitant use of albendazole with irasiquantel, dexamethasone and cimetidine may increase the concentration of albendazole sulfoxide in the blood. Concomitant use with carbamazepine, phenytoin, phenobarbital and ginseng can lead to a decrease in the concentration of the drug albendazole in the gut.

Overdose

Treatment: gastric lavage, activated charcoal. If necessary, conduct symptomatic therapy.

Shelf suitability

3 Year

Deystvuyuschee substances

Albendazole

dosage form

dosage form

tablets