Artra tab. p / o captivity. # 120

Release form, composition and packaging

Film-coated tablets from white to white with a yellowish tinge, interspersed, oval, biconvex, with ARTRA" engraving on one side, with a specific odor

1 tab.

chondroitin sodium sulfate 500 mg

glucosamine hydrochloride 500 mg

calcium sulfate disubstituted - 230 mg, microcrystalline cellulose - 185 mg, sodium croscarmellose - 80 mg, stearic acid - 70 mg, magnesium stearate - 10 mg

Shell composition: hydroxypropyl methylcellulose - 35 mg, titanium dioxide (E171) - 8.2 mg, triacetin - 6.8 mg

30 pcs.

- bottles made of high density polyethylene (1) - cardboard packs.

60 pcs.

- bottles made of high density polyethylene (1) - cardboard packs.

100 pieces.

- bottles made of high density polyethylene (1) - cardboard packs.

120 pcs.

- bottles made of high density polyethylene (1) - cardboard packs.

pharmachologic effect

Cartilage regeneration stimulator

Glucosamine and chondroitin sodium sulfate are involved in the biosynthesis of connective tissue, helping to prevent the destruction of cartilage, stimulating tissue regeneration.

The introduction of exogenous glucosamine enhances the production of cartilage matrix and provides nonspecific protection, incl.

from NSAIDs and GCS.

The drug has a moderate anti-inflammatory effect.

Chondroitin sodium sulfate, whether absorbed intact or as separate components, serves as an additional substrate for the formation of a healthy cartilage matrix.

Stimulates the formation of proteoglycans and collagen type II, and also protects the cartilage matrix from enzymatic degradation (by suppressing the activity of hyaluronidase) and from the damaging effects of free radicals

maintains the viscosity of synovial fluid, stimulates cartilage repair mechanisms and inhibits the activity of those enzymes (elastase, hyaluronidase) that break down cartilage.

When treating osteoarthritis, it relieves symptoms of the disease and reduces the need for NSAIDs.

Pharmacokinetics

Absorption The bioavailability of glucosamine when taken orally is 25% (due to the "first pass" effect through the liver).

Bioavailability of chondroitin sulfate - 13%

Distribution Distributed in tissues: the highest concentrations of glucosamine are found in the liver, kidneys and articular cartilage.

About 30% of the dose taken persists for a long time in bone and muscle tissue

Excretion Glucosamine is excreted mainly in the urine unchanged

partly with feces.

T1 / 2 glucosamine - 68 hours

Indications for use

osteoarthritis of the peripheral joints and spine.

Contraindications for use

severe renal dysfunction

hypersensitivity to drug components

With care: bleeding or bleeding tendency, bronchial asthma, diabetes mellitus.

Dosage regimen

Inside, adults and children over 15 years of age are prescribed 1 tab.

2 times / day for the first three weeks

1 tab.

1 time / day for the next weeks and months

A stable therapeutic effect is achieved when taking the drug for at least 6 months.

Overdose

To date, no cases of Artra drug overdose have been reported

Treatment: gastric lavage, symptomatic therapy.

Side effect

Glucosamine From the digestive system: possible mild gastrointestinal dysfunction - epigastric pain, flatulence, diarrhea, constipation

From the side of the central nervous system: dizziness

Glucosamine and chondroitin Other: allergic reactions.

Drug interactions

With simultaneous use, it is possible to enhance the action of anticoagulants and antiplatelet agents

Artra increases the absorption of tetracyclines, reduces the effect of semi-synthetic penicillins

The drug is compatible with GCS.

Application during pregnancy and lactation

Artra is not recommended for use during pregnancy and lactation.

Special instructions Use in pediatrics CL

Name ENG

ARTRA

Clinical and pharmacological group

A drug that stimulates the regeneration of cartilage tissue

ATX code

Other drugs for the treatment of diseases of the musculoskeletal system

Dosage

500mg + 500mg

Structure

Active active ingredients: Glucosamine hydrochloride 500 mg Chondroitin sodium sulfate 500 mg Excipients: calcium phosphate disubstituted, microcrystalline cellulose, sodium croscarmellose, stearic acid, magnesium stearate.

Sheath: Hydroxypropyl methylcellulose, titanium dioxide (E171), triacetin.

Indications

Osteoarthritis of the peripheral joints and spine.

INN / Active ingredient

chondroitin sodium sulfate, glucosamine hydrochloride

Contraindications

Hypersensitivity, severe renal dysfunction.

With care: bleeding or bleeding tendency, bronchial asthma, diabetes mellitus.

Storage conditions and periods

At a temperature not higher than 25 degrees.

Expiration date: 2 years

Specifications

Scope of the medicinal product

Musculoskeletal system

Release form

Tablet

Manufacturer country

USA

Package quantity, pcs

120

Way of introduction

Through the mouth

Vacation conditions

Without recipe

Brand name

Unipharm

The amount of the dosage form in the primary package

120 pcs.

Primary packaging type

Bottle

Type of consumer packaging

Pack of cardboard

Pharmaco-therapeutic group

Tissue repair stimulant

Dosage form

Film-coated tablets

Expiration date in days

730

Package weight, g

295

Category

:

Joints

,

Treatment of diseases of the musculoskeletal system

,

Synovial fluid

,

Bone metabolism

Mode of application

:

Inside.

Adults and children over 15 years of age are prescribed 1 tab.

2 times a day for the first three weeks

1 tab.

1 time / day for the next weeks and months.

A stable therapeutic effect is achieved when the drug is taken for at least 6 months.

Anatomical and therapeutic characteristics

:

M09AX Other drugs for the treatment of diseases of the musculoskeletal system

Dosage (volume) of the substance in the preparation

:

1 tab .: glucosamine hydrochloride 500 mg, chondroitin sodium sulfate 500 mg

Information on technical characteristics, delivery set, country of manufacture "